DMT-2'-F-iBu-G (Synonyms: 5'-DMT-2'-F-ibu-dG)

Cat. No.: HY-W115309 Purity: ≥97.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

DMT-2'-F-iBu-G (5'-DMT-2'-F-ibu-dG) is a modified oligonucleotide. 2'-deoxy-2'-fluoro-modified oligonucleotides shows high nuclease resistant and retained exceptional binding affinity to the RNA targets.

For research use only. We do not sell to patients.

DMT-2'-F-iBu-G Chemical Structure

CAS No. : 144089-96-3

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	Get quote
10 g	Get quote

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Description

Molecular Weight

657.69

Formula

C₃₅H₃₆FN₅O₇

CAS No.

144089-96-3

Appearance

Solid

Color

White to off-white

SMILES

F[C@@H]1[C@H](O)[C@@H](COC(C2=CC=C(OC)C=C2)(C3=CC=C(OC)C=C3)C4=CC=CC=C4)O[C@H]1N(C=N5)C(NC(NC(C(C)C)=O)=N6)=C5C6=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (152.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5205 mL	7.6024 mL	15.2047 mL
5 mM	0.3041 mL	1.5205 mL	3.0409 mL
10 mM	0.1520 mL	0.7602 mL	1.5205 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (250 KB) HNMR (138 KB)

Handling Instructions (2659 KB)

References

[1]. Kawasaki AM, et al. Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets. J Med Chem. 1993 Apr 2;36(7):831-41. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5205 mL	7.6024 mL	15.2047 mL	38.0118 mL
	5 mM	0.3041 mL	1.5205 mL	3.0409 mL	7.6024 mL
	10 mM	0.1520 mL	0.7602 mL	1.5205 mL	3.8012 mL
	15 mM	0.1014 mL	0.5068 mL	1.0136 mL	2.5341 mL
	20 mM	0.0760 mL	0.3801 mL	0.7602 mL	1.9006 mL
	25 mM	0.0608 mL	0.3041 mL	0.6082 mL	1.5205 mL
	30 mM	0.0507 mL	0.2534 mL	0.5068 mL	1.2671 mL
	40 mM	0.0380 mL	0.1901 mL	0.3801 mL	0.9503 mL
	50 mM	0.0304 mL	0.1520 mL	0.3041 mL	0.7602 mL
	60 mM	0.0253 mL	0.1267 mL	0.2534 mL	0.6335 mL
	80 mM	0.0190 mL	0.0950 mL	0.1901 mL	0.4751 mL
	100 mM	0.0152 mL	0.0760 mL	0.1520 mL	0.3801 mL

DMT-2'-F-iBu-G Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DMT-2'-F-iBu-G144089-96-35'-DMT-2'-F-ibu-dGNucleoside Antimetabolite/Analogoligonucleotidenuclease resistantRNA targetsInhibitorinhibitorinhibit

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