1. Anti-infection Cell Cycle/DNA Damage
  2. Bacterial DNA/RNA Synthesis Topoisomerase
  3. DNA Gyrase-IN-6

Antibacterial agent 138 is a benzothiazole inhibitor of bacterial DNA gyrase and topoisomerase IV. Antibacterial agent 138 exhibits favorable solubility and plasma protein binding. Antibacterial agent 138 has antibacterial activity against Gram-positive and Gram-negative strains. Antibacterial agent 138 is a dual GyrB and ParE inhibitor.

For research use only. We do not sell to patients.

DNA Gyrase-IN-6 Chemical Structure

DNA Gyrase-IN-6 Chemical Structure

CAS No. : 3034242-80-0

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Description

Antibacterial agent 138 is a benzothiazole inhibitor of bacterial DNA gyrase and topoisomerase IV. Antibacterial agent 138 exhibits favorable solubility and plasma protein binding. Antibacterial agent 138 has antibacterial activity against Gram-positive and Gram-negative strains. Antibacterial agent 138 is a dual GyrB and ParE inhibitor[1].

IC50 & Target

DNA gyrase, Topoisomerase IV[1]

In Vitro

Antibacterial agent 138 (compound 7a) inhibits DNA gyrase and topoisomerase IV from S. aureus (IC50=1.22 nM and 8.0 nM, repsectivley), E. coli (IC50=<10 nM and 44 nM, repsectivley), A. baumannii (IC50=2.42 nM and 119.7 nM, repsectivley), and P. aeruginosa (IC50=<10 nM and 27.5 nM, repsectivley) with low nanomolar ranges[1].
Antibacterial agent 138 (up to 100 μM) shows no cytotoxicity on a breast cancer MCF-7 cell line and a liver cancer HepG2 cell[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antibacterial agent 138 (compound 7a) (25 and 50 mg/kg; iv; single dose) shows bactericidal activity in neutropenic mouse thigh infection model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

455.32

Formula

C18H16Cl2N4O4S

CAS No.
SMILES

CC1=C(C(Cl)=C(N1)C(NC2=NC3=C(S2)C=C(C=C3N4CCOCC4)C(O)=O)=O)Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
DNA Gyrase-IN-6
Cat. No.:
HY-149925
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