1. Others Neuronal Signaling
  2. Isotope-Labeled Compounds Cholinesterase (ChE)
  3. Donepezil-d7 hydrochloride

Donepezil-d7 hydrochloride  (Synonyms: E2020-d7)

Cat. No.: HY-14566S Purity: ≥99.0%
SDS COA Handling Instructions

Donepezil-d7 (hydrochloride) is the deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].

For research use only. We do not sell to patients.

Donepezil-d<sub>7</sub> hydrochloride Chemical Structure

Donepezil-d7 hydrochloride Chemical Structure

CAS No. : 1261394-20-0

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2500 μg USD 623 In-stock

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Based on 1 publication(s) in Google Scholar

Other Forms of Donepezil-d7 hydrochloride:

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Description

Donepezil-d7 (hydrochloride) is the deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

423.00

Formula

C24H23D7ClNO3

CAS No.
Unlabeled CAS

120011-70-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=CC(OC)=C(OC)C=C2CC1CC3CCN(CC3)C([2H])([2H])C4=C([2H])C([2H])=C([2H])C([2H])=C4[2H].Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥99.0%

References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Donepezil-d7 hydrochloride
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HY-14566S
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