DORA 42

Cat. No.: HY-113555: FAQs
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DORA 42 is a dual orexin 1 and orexin 2 receptor antagonist with sleep efficacy in rats. DORA 42 is promising for research of insomnia.

For research use only. We do not sell to patients.

DORA 42 Chemical Structure

CAS No. : 1030377-48-0

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OX₂ Receptor OX₁ Receptor

Biological Activity
Purity & Documentation
References
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Description

DORA 42 is a dual orexin 1 and orexin 2 receptor antagonist with sleep efficacy in rats. DORA 42 is promising for research of insomnia^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	28 nM Compound: 42	Antagonist activity at human orexin-1 receptor expressed in CHO cells assessed as inhibition of Ala-6, 12-induced responses by FLIPR assay Antagonist activity at human orexin-1 receptor expressed in CHO cells assessed as inhibition of Ala-6, 12-induced responses by FLIPR assay	[PMID: 24704030]
CHO	IC₅₀	29 nM Compound: 42	Antagonist activity at human orexin-2 receptor expressed in CHO cells assessed as inhibition of Ala-6, 12-induced responses by FLIPR assay Antagonist activity at human orexin-2 receptor expressed in CHO cells assessed as inhibition of Ala-6, 12-induced responses by FLIPR assay	[PMID: 24704030]

Molecular Weight

448.54

Formula

C₂₂H₂₄N₈OS

CAS No.

1030377-48-0

SMILES

NC1=C2C(SC=C2C)=NC(N3CCN([C@@H](CC3)C)C(C4=C(N5N=CC=N5)C=CC=C4)=O)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Roecker AJ, et al. Discovery of dual orexin receptor antagonists with rat sleep efficacy enabled by expansion of the acetonitrile-assisted/diphosgene-mediated 2,4-dichloropyrimidine synthesis. Bioorg Med Chem Lett. 2014 May 1;24(9):2079-85. [Content Brief]

DORA 42 Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DORA 421030377-48-0DORA42DORA-42Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT Receptororexin 1 receptororexin 2 receptorsleep efficacyratsinsomniaInhibitorinhibitorinhibit

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