2. Anti-infection
  3. Bacterial Antibiotic
  4. Doripenem

Doripenem (S 4661), a 1β-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria.

For research use only. We do not sell to patients.

Doripenem Chemical Structure

Doripenem Chemical Structure

CAS No. : 148016-81-3

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5 mg USD 35 In-stock
10 mg USD 55 In-stock
25 mg USD 90 In-stock
50 mg USD 150 In-stock
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Based on 5 publication(s) in Google Scholar

Other Forms of Doripenem:

Doripenem Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Doripenem (S 4661), a 1β-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria[1][2].

IC50 & Target

β-lactam

 

In Vivo

Doripenem (S 4661; MIC range of 2 to 16 μg/ml; Subcutaneous; 1-h and 4-h infusion; 0.2 ml injections) monohydrate demonstrates antibacterial killing for P. aeruginosa[1].
Doripenem (10, 50, 150 mg/kg; 0.2-ml volumes; subcutaneously 2 h) has a T1/2 of 0.41 hours, a CL of 673.9 mL/h•kg for mice with 10 mg/kg[1].
Pharmacokinetic Parameters of Doripenem in mice[1].

SC (10 mg/kg) SC (50 mg/kg) SC (150 mg/kg)
Tmax (h) 0.25 0.38 0.22
Cmax (μg/mL) 16.3 59.7 194.4
AUC0-24 (ng∗h /mL) 13.5 62.4 168
t1/2 (h) 0.41 0.34 0.44
CL (mL/h/kg) 673.9 783.3 850.5
V (mL/kg) 400.7 384.7 545.8

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Specific-pathogen-free, female ICR mice weighing approximately 25 g with P. aeruginosa-infected thighs[1]
Dosage: MIC range of 2 to 16 μg/ml
Administration: Subcutaneous; 1-h and 4-h infusion; 0.2 ml injections
Result: Demonstrated antibacterial killing for P. aeruginosa.
Clinical Trial
Molecular Weight

420.50

Formula

C15H24N4O6S2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C(N12)=C(S[C@@H]3CN[C@H](CNS(=O)(N)=O)C3)[C@H](C)[C@]2([H])[C@@H]([C@H](O)C)C1=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 200 mg/mL (475.62 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3781 mL 11.8906 mL 23.7812 mL
5 mM 0.4756 mL 2.3781 mL 4.7562 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 5 mg/mL (11.89 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 5 mg/mL (11.89 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.91%

SDS (393 KB)

COA (252 KB) RP-HPLC (205 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3781 mL 11.8906 mL 23.7812 mL 59.4530 mL
5 mM 0.4756 mL 2.3781 mL 4.7562 mL 11.8906 mL
10 mM 0.2378 mL 1.1891 mL 2.3781 mL 5.9453 mL
15 mM 0.1585 mL 0.7927 mL 1.5854 mL 3.9635 mL
20 mM 0.1189 mL 0.5945 mL 1.1891 mL 2.9727 mL
25 mM 0.0951 mL 0.4756 mL 0.9512 mL 2.3781 mL
30 mM 0.0793 mL 0.3964 mL 0.7927 mL 1.9818 mL
40 mM 0.0595 mL 0.2973 mL 0.5945 mL 1.4863 mL
50 mM 0.0476 mL 0.2378 mL 0.4756 mL 1.1891 mL
60 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.9909 mL
80 mM 0.0297 mL 0.1486 mL 0.2973 mL 0.7432 mL
100 mM 0.0238 mL 0.1189 mL 0.2378 mL 0.5945 mL
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Doripenem Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Doripenem148016-81-3S 4661S4661S-4661BacterialAntibiotic1β-methyl parenteral carbapenemGram-positiveGram-negativeInhibitorinhibitorinhibit

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