Doripenem  (Synonyms: S 4661)

Doripenem (S 4661), a 1β-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria^[1][2].

Doripenem (S 4661; MIC range of 2 to 16 μg/ml; Subcutaneous; 1-h and 4-h infusion; 0.2 ml injections) monohydrate demonstrates antibacterial killing for P. aeruginosa^[1].
Doripenem (10, 50, 150 mg/kg; 0.2-ml volumes; subcutaneously 2 h) has a T_1/2 of 0.41 hours, a CL of 673.9 mL/h•kg for mice with 10 mg/kg^[1].
Pharmacokinetic Parameters of Doripenem in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

420.50

C₁₅H₂₄N₄O₆S₂

148016-81-3

Solid

Off-white to light yellow

O=C(C(N12)=C(S[C@@H]3CN[C@H](CNS(=O)(N)=O)C3)[C@H](C)[C@]2([H])[C@@H]([C@H](O)C)C1=O)O

Room temperature in continental US; may vary elsewhere.

• [1]. Aryun Kim, et al. In vivo pharmacodynamic profiling of doripenem against Pseudomonas aeruginosa by simulating human exposures. Antimicrob Agents Chemother. 2008 Jul;52(7):2497-502.  [Content Brief]

  [2]. Jones RN, et al. Doripenem (S-4661), a novel carbapenem: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations. J Antimicrob Chemother. 2004 Jul;54(1):144-54. Epub 2004 Jun 9.  [Content Brief]