2. Antibody-drug Conjugate/ADC Related
  3. Radionuclide-Drug Conjugates (RDCs)
  4. DOTA-bis(tert-butyl)ester

DOTA-bis(tert-butyl)ester is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide conjugates (RDCs). DOTA-bis(tert-butyl)ester can be conjugated with different salts to form different metal chelators, such as (HY-B1244) hydrochloride to obtain DOTA-MN2. DOTA-MN2 can be reacted with [67]Ga-citrate to obtain radiolabeling. When (67)Ga-DOTA-MN2 is incubated in phosphate buffer solution or mouse plasma for 24 hours, it does not undergo significant decomposition. In the biodistribution experiment of NFSa tumor mice, it has high tumor uptake and rapid plasma clearance, and is a good material for SPECT and PET studies.

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DOTA-bis(tert-butyl)ester Chemical Structure

DOTA-bis(tert-butyl)ester Chemical Structure

CAS No. : 913542-71-9

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Description

DOTA-bis(tert-butyl)ester is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide conjugates (RDCs). DOTA-bis(tert-butyl)ester can be conjugated with different salts to form different metal chelators, such as (HY-B1244) hydrochloride to obtain DOTA-MN2. DOTA-MN2 can be reacted with [67]Ga-citrate to obtain radiolabeling. When (67)Ga-DOTA-MN2 is incubated in phosphate buffer solution or mouse plasma for 24 hours, it does not undergo significant decomposition. In the biodistribution experiment of NFSa tumor mice, it has high tumor uptake and rapid plasma clearance, and is a good material for SPECT and PET studies.

IC50 & Target

RDC Bifunctional Chelator

 

Molecular Weight

516.63

Formula

C24H44N4O8
CAS No.
SMILES

O=C(OC(C)(C)C)CN1CCN(CC(O)=O)CCN(CC(OC(C)(C)C)=O)CCN(CC(O)=O)CC1
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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DOTA-bis(tert-butyl)ester Related Classifications

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Keywords:

DOTA-bis(tert-butyl)ester913542-71-9Radionuclide-Drug Conjugates (RDCs)Inhibitorinhibitorinhibit

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