2. GPCR/G Protein Antibody-drug Conjugate/ADC Related Neuronal Signaling
  3. Somatostatin Receptor Radionuclide-Drug Conjugates (RDCs)
  4. DOTA-JR11

DOTA-JR11  (Synonyms: Satoreotide tetraxetan)

Cat. No.: HY-P5128 Purity: 98.81%
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DOTA-JR11 is a somatostatin receptor 2 （SSTR2）antagonist. DOTA-JR11 can be labeled by 68Ga, used for paired imaging in neuroendocrine tumors (NETs) research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

DOTA-JR11 Chemical Structure

DOTA-JR11 Chemical Structure

CAS No. : 1039726-31-2

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1 mg USD 155 In-stock
5 mg USD 388 In-stock
10 mg USD 620 In-stock
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Based on 1 publication(s) in Google Scholar

DOTA-JR11 Related Antibodies

Top Publications Citing Use of Products

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SSTR1 SSTR2 SSTR3 SSTR5 SSTR4

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Description

DOTA-JR11 is a somatostatin receptor 2 （SSTR2）antagonist. DOTA-JR11 can be labeled by 68Ga, used for paired imaging in neuroendocrine tumors (NETs) research[1].

IC50 & Target

RDC Peptide

 

In Vitro

[68Ga]Ga-DOTA-JR11 (30 ± 5 GBq/μmol, 5-120 min) shows stable uptake in HEK293-SSTR2 cells, suitable for SSTR2-targeted research[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DOTA-JR11 Related Antibodies
In Vivo

[68Ga]Ga-DOTA-JR11 (1.85 MBq, i.v., single dose) shows high tumor uptake in HEK293-SSTR2 tumor model mice, suitable for tumor imaging[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HEK293-SSTR2 tumor mice model[2]
Dosage: 1.85 MBq
Administration: Intravenous injection (i.v.), single dose, measured at 5, 30, 60, and 120 min
Result: Caused tumor uptake to peak at 60 minutes, significantly higher than uptake in other organs.
Molecular Weight

1689.27

Formula

C74H98ClN19O21S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

DOTA-[p-Cl-Phe-cyclo(D-Cys-Phe-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr-NH2]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (14.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5920 mL 2.9599 mL 5.9197 mL
5 mM 0.1184 mL 0.5920 mL 1.1839 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5920 mL 2.9599 mL 5.9197 mL 14.7993 mL
5 mM 0.1184 mL 0.5920 mL 1.1839 mL 2.9599 mL
10 mM 0.0592 mL 0.2960 mL 0.5920 mL 1.4799 mL
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DOTA-JR11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DOTA-JR111039726-31-2Satoreotide tetraxetanSomatostatin ReceptorRadionuclide-Drug Conjugates (RDCs)SSTRsSSTR68Gapaired imagingneuroendocrine tumorsHEK293-SSTR2 cellsHEK293-SSTR2 tumor mice modelInhibitorinhibitorinhibit

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