2. GPCR/G Protein
  3. PTHR
  4. DS69910557

DS69910557 is a potent, selective and orally activehuman parathyroid hormone receptor 1 (hPTHR1) antagonist. DS69910557 has antagonistic activity for PTHR1 with an IC50 value of 0.08 μM. DS69910557 can be used for the research of hyperparathyroidism, hypercalcemia of malignancy and osteoporosis.

For research use only. We do not sell to patients.

DS69910557 Chemical Structure

DS69910557 Chemical Structure

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 915 In-stock
Solution
10 mM * 1 mL in DMSO USD 915 In-stock
Solid
5 mg USD 680 In-stock
10 mg USD 1100 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Description

DS69910557 is a potent, selective and orally activehuman parathyroid hormone receptor 1 (hPTHR1) antagonist. DS69910557 has antagonistic activity for PTHR1 with an IC50 value of 0.08 μM. DS69910557 can be used for the research of hyperparathyroidism, hypercalcemia of malignancy and osteoporosis[1].

IC50 & Target

IC50: 0.08 μM (PTHR1)[1].
In Vitro

DS69910557 (compound 19e) has highly potent antagonistic activity for PTHR1 with an IC50 value of 0.08 μM[1].
DS69910557 (3 μM) exhibits excellent selectivity against human ether-a-go-go-related-gene (hERG) channel[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DS69910557 Related Antibodies
In Vivo

DS69910557 (compound 19e) (p.o.; 5mg/kg) has potency to decrease the plasma calcium concentration in rats in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[1]
Dosage: 5mg/kg
Administration: PO
Result: Showed excellent PK profile, high maximum plasma concentration and plasma exposure in rats.
Molecular Weight

611.53

Formula

C32H33Cl2FN4O3
Appearance

Solid

Color

Off-white to light yellow

SMILES

ClC(C=N1)=CC(C2=C(C=C(Cl)C=C2)N3C4=CC=C(N5CC(F)(CN[C@@H]6CC[C@@H](C(O)=O)CC6)C5)C=C4)=C1C(C)(C)C3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (163.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6352 mL 8.1762 mL 16.3524 mL
5 mM 0.3270 mL 1.6352 mL 3.2705 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.47%

SDS (251 KB)

COA (261 KB) HNMR (296 KB) LCMS (96 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6352 mL 8.1762 mL 16.3524 mL 40.8811 mL
5 mM 0.3270 mL 1.6352 mL 3.2705 mL 8.1762 mL
10 mM 0.1635 mL 0.8176 mL 1.6352 mL 4.0881 mL
15 mM 0.1090 mL 0.5451 mL 1.0902 mL 2.7254 mL
20 mM 0.0818 mL 0.4088 mL 0.8176 mL 2.0441 mL
25 mM 0.0654 mL 0.3270 mL 0.6541 mL 1.6352 mL
30 mM 0.0545 mL 0.2725 mL 0.5451 mL 1.3627 mL
40 mM 0.0409 mL 0.2044 mL 0.4088 mL 1.0220 mL
50 mM 0.0327 mL 0.1635 mL 0.3270 mL 0.8176 mL
60 mM 0.0273 mL 0.1363 mL 0.2725 mL 0.6814 mL
80 mM 0.0204 mL 0.1022 mL 0.2044 mL 0.5110 mL
100 mM 0.0164 mL 0.0818 mL 0.1635 mL 0.4088 mL
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DS69910557 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DS69910557DS 69910557DS-69910557PTHRParathyroid hormone receptororalhuman parathyroid hormone receptor 1 (hPTHR1)hyperparathyroidismhypercalcemiamalignancyosteoporosisInhibitorinhibitorinhibit

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