DSPE-PEG-Folate, MW 3350

Name: DSPE-PEG-Folate, MW 3350
Brand: MedChemExpress
SKU: HY-144009
Rating: 4.5 (1 reviews)

Cat. No.: HY-144009 Purity: 95.16%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

DSPE-PEG-Folate, MW 3350 is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research.

For research use only. We do not sell to patients.

DSPE-PEG-Folate, MW 3350 Chemical Structure

CAS No. : 1236288-25-7

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Nanoparticles constructed with DSPE-PEG-Folate and anticancer drugs enter cells mainly through the endocytosis pathway mediated by FA receptors. The nanoparticles mainly accumulate in the cytoplasm, while the released drugs are distributed in the cytoplasm and nucleus, which can effectively deliver drugs to the nucleus to play a role. DSPE-PEG-Folate can increase the elimination half-life of the drug and prolong the blood circulation time^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

3400.00

Formula

C₆₅H₁₁₄N₁₁O₁₆P

CAS No.

1236288-25-7

Appearance

Solid

Color

Yellow to brown

SMILES

O=C(NCCOP(O)(OCC(COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCCCC)=O)=O)OCCOCCNC(CCC(C(O)=O)NC(C1=CC=C(NCC(N=C23)=CNC3=NC(N)=NC2=O)C=C1)=O)=O.N.N.[n]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (14.71 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.2941 mL	1.4706 mL	2.9412 mL
5 mM	0.0588 mL	0.2941 mL	0.5882 mL
10 mM	0.0294 mL	0.1471 mL	0.2941 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.16%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (242 KB) HNMR (345 KB) RP-HPLC (237 KB)

Handling Instructions (2659 KB)

References

[1]. Li Y, et, al. Self-Assembled Nanoparticles Based on Amphiphilic Anticancer Drug-Phospholipid Complex for Targeted Drug Delivery and Intracellular Dual-Controlled Release. ACS Appl Mater Interfaces. 2015 Aug 19;7(32):17573-81. [Content Brief]

[2]. Werner ME, et, al. Folate-targeted nanoparticle delivery of chemo- and radiotherapeutics for the treatment of ovarian cancer peritoneal metastasis. Biomaterials. 2011 Nov;32(33):8548-54. [Content Brief]

[3]. Patlolla RR, et al. Folate-targeted etoposide-encapsulated lipid nanospheres. J Drug Target. 2008 May;16(4):269-75. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.2941 mL	1.4706 mL	2.9412 mL	7.3529 mL
	5 mM	0.0588 mL	0.2941 mL	0.5882 mL	1.4706 mL
	10 mM	0.0294 mL	0.1471 mL	0.2941 mL	0.7353 mL