2. PROTAC
  3. PROTACs
  4. dTAG-13-NEG

dTAG-13-NEG is a negative control of dTAG-13. dTAG-13 (HY-114421), a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest.

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dTAG-13-NEG Chemical Structure

dTAG-13-NEG Chemical Structure

CAS No. : 2451573-90-1

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Other Forms of dTAG-13-NEG:

dTAG-13-NEG Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

dTAG-13-NEG is a negative control of dTAG-13. dTAG-13 (HY-114421), a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest[1].

Molecular Weight

1063.19

Formula

C58H70N4O15
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C(OCCCCCCNC(COC3=C(C=CC=C3)[C@@H](CCC4=CC(OC)=C(C=C4)OC)OC([C@H]5N(CCCC5)C([C@H](C6=CC(OC)=C(C(OC)=C6)OC)CC)=O)=O)=O)C=CC=C2C(N1C7C(N(C(CC7)=O)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (94.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9406 mL 4.7028 mL 9.4057 mL
5 mM 0.1881 mL 0.9406 mL 1.8811 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9406 mL 4.7028 mL 9.4057 mL 23.5141 mL
5 mM 0.1881 mL 0.9406 mL 1.8811 mL 4.7028 mL
10 mM 0.0941 mL 0.4703 mL 0.9406 mL 2.3514 mL
15 mM 0.0627 mL 0.3135 mL 0.6270 mL 1.5676 mL
20 mM 0.0470 mL 0.2351 mL 0.4703 mL 1.1757 mL
25 mM 0.0376 mL 0.1881 mL 0.3762 mL 0.9406 mL
30 mM 0.0314 mL 0.1568 mL 0.3135 mL 0.7838 mL
40 mM 0.0235 mL 0.1176 mL 0.2351 mL 0.5879 mL
50 mM 0.0188 mL 0.0941 mL 0.1881 mL 0.4703 mL
60 mM 0.0157 mL 0.0784 mL 0.1568 mL 0.3919 mL
80 mM 0.0118 mL 0.0588 mL 0.1176 mL 0.2939 mL
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dTAG-13-NEG Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

dTAG-13-NEG2451573-90-1PROTACsInhibitorinhibitorinhibit

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