2. Metabolic Enzyme/Protease
  3. TrxR
  4. DVD-445

DVD-445 (Compound 7) is a potent peptidomimetic covalent thioredoxin reductase 1 (TrxR1) inhibitor with an IC50 of 0.60 μM for rat TrxR1. DVD-445 has good anticancer application.

For research use only. We do not sell to patients.

DVD-445 Chemical Structure

DVD-445 Chemical Structure

CAS No. : 2375846-41-4

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 176 In-stock
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5 mg USD 160 In-stock
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25 mg USD 550 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

DVD-445 Related Antibodies

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Description

DVD-445 (Compound 7) is a potent peptidomimetic covalent thioredoxin reductase 1 (TrxR1) inhibitor with an IC50 of 0.60 μM for rat TrxR1. DVD-445 has good anticancer application[1].

IC50 & Target

IC50: 0.60 μM (rat TrxR1)[1]
In Vitro

DVD-445 (Compound 7) shows a cytotoxic effect in SH-SY5Y, U87, HaCaT cell lines and PBMCs with IC50s of 10.99 μM, 9.70 μM, 8.30 μM, 55.71 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DVD-445 Related Antibodies
Molecular Weight

458.50

Formula

C25H28F2N2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OCCN(C(C1=CC=C(F)C=C1)C(NC(C)(C)C)=O)C)/C=C/C(C2=CC=C(F)C=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (218.10 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1810 mL 10.9051 mL 21.8103 mL
5 mM 0.4362 mL 2.1810 mL 4.3621 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1810 mL 10.9051 mL 21.8103 mL 54.5256 mL
5 mM 0.4362 mL 2.1810 mL 4.3621 mL 10.9051 mL
10 mM 0.2181 mL 1.0905 mL 2.1810 mL 5.4526 mL
15 mM 0.1454 mL 0.7270 mL 1.4540 mL 3.6350 mL
20 mM 0.1091 mL 0.5453 mL 1.0905 mL 2.7263 mL
25 mM 0.0872 mL 0.4362 mL 0.8724 mL 2.1810 mL
30 mM 0.0727 mL 0.3635 mL 0.7270 mL 1.8175 mL
40 mM 0.0545 mL 0.2726 mL 0.5453 mL 1.3631 mL
50 mM 0.0436 mL 0.2181 mL 0.4362 mL 1.0905 mL
60 mM 0.0364 mL 0.1818 mL 0.3635 mL 0.9088 mL
80 mM 0.0273 mL 0.1363 mL 0.2726 mL 0.6816 mL
100 mM 0.0218 mL 0.1091 mL 0.2181 mL 0.5453 mL
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DVD-445 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DVD-4452375846-41-4DVD445DVD 445TrxRThioredoxin ReductaseInhibitorinhibitorinhibit

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