(E)-5-O-Cinnamoylquinic acid

Name: (E)-5-O-Cinnamoylquinic acid
Brand: MedChemExpress
SKU: HY-N8224A
Rating: 4.5 (1 reviews)

Cat. No.: HY-N8224A Purity: 99.49%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

(E)-5-O-Cinnamoylquinic acid is the isomer of 5-O-Cinnamoylquinic acid. 5-O-Cinnamoylquinic acid is a co-pigment. 5-O-Cinnamoylquinic acid could form the stable blue solution to clarify the mechanism of blue sepal-color development of hydrangea.

For research use only. We do not sell to patients.

(E)-5-O-Cinnamoylquinic acid Chemical Structure

CAS No. : 6470-68-4

Size	Price	Stock	Quantity
5 mg	USD 235	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of (E)-5-O-Cinnamoylquinic acid:

5-O-Cinnamoylquinic acid Get quote

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

322.31

Formula

C₁₆H₁₈O₇

CAS No.

6470-68-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(/C=C/C1=CC=CC=C1)O[C@H]2C[C@@](O)(C[C@@H]([C@H]2O)O)C(O)=O.[(E)]

Structure Classification

Phenylpropanoids

Ketones, Aldehydes, Acids

Initial Source

Animals

human gastric juice

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 50 mg/mL (155.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1026 mL	15.5130 mL	31.0260 mL
5 mM	0.6205 mL	3.1026 mL	6.2052 mL
10 mM	0.3103 mL	1.5513 mL	3.1026 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (3.88 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (3.88 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.25 mg/mL (3.88 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.49%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (250 KB) HNMR (157 KB) CNMR (140 KB) RP-HPLC (252 KB) MS (130 KB)

Handling Instructions (2659 KB)

References

[1]. Kondo T, et, al. Essential structure of co-pigment for blue sepal-color development of hydrangea. Tetrahedron Letters. 2005 Sep 26; 46(39): 6645-6649.

[2]. Hanson KR. Chlorogenic acid biosynthesis. Chemical synthesis and properties of the mono-O-cinnamoylquinic acids. Biochemistry. 1965 Dec;4(12):2719-31. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1026 mL	15.5130 mL	31.0260 mL	77.5651 mL
	5 mM	0.6205 mL	3.1026 mL	6.2052 mL	15.5130 mL
	10 mM	0.3103 mL	1.5513 mL	3.1026 mL	7.7565 mL
	15 mM	0.2068 mL	1.0342 mL	2.0684 mL	5.1710 mL
	20 mM	0.1551 mL	0.7757 mL	1.5513 mL	3.8783 mL
	25 mM	0.1241 mL	0.6205 mL	1.2410 mL	3.1026 mL
	30 mM	0.1034 mL	0.5171 mL	1.0342 mL	2.5855 mL
	40 mM	0.0776 mL	0.3878 mL	0.7757 mL	1.9391 mL
	50 mM	0.0621 mL	0.3103 mL	0.6205 mL	1.5513 mL
	60 mM	0.0517 mL	0.2586 mL	0.5171 mL	1.2928 mL
	80 mM	0.0388 mL	0.1939 mL	0.3878 mL	0.9696 mL
	100 mM	0.0310 mL	0.1551 mL	0.3103 mL	0.7757 mL