(E/Z)-Demethoxycurcumin (Synonyms: p-Hydroxycinnamoyl-feruloylmethane)

Cat. No.: HY-N0006A Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

(E/Z)-Demethoxycurcumin (p-Hydroxycinnamoyl-feruloylmethane) is a curcuminoid isolated from curcuma species, with anticoagulative active.

For research use only. We do not sell to patients.

(E/Z)-Demethoxycurcumin Chemical Structure

CAS No. : 24939-17-1

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
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100 mg	Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of (E/Z)-Demethoxycurcumin:

Demethoxycurcumin In-stock

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Description

(E/Z)-Demethoxycurcumin (p-Hydroxycinnamoyl-feruloylmethane) is a curcuminoid isolated from curcuma species, with anticoagulative active^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	> 100 μM Compound: DC	Cytotoxicity against human A431 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human A431 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]
A549	IC₅₀	28.2 μM Compound: DC	Cytotoxicity against human A549 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human A549 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]
DLD-1	IC₅₀	> 40 μM Compound: DC	Cytotoxicity against human DLD1 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human DLD1 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]
MCF7	IC₅₀	92.1 μM Compound: DC	Cytotoxicity against human MCF7 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human MCF7 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]
MDA-MB-231	IC₅₀	9 mM Compound: DMC	Increase in MMP3 level in human MDA-MB-231 cells after 24 hrs by ELISA Increase in MMP3 level in human MDA-MB-231 cells after 24 hrs by ELISA	[PMID: 31336310]
WRL68	IC₅₀	26.3 μM Compound: DC	Cytotoxicity against human WRL68 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human WRL68 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]

Molecular Weight

338.35

Formula

C₂₀H₁₈O₅

CAS No.

24939-17-1

Appearance

Solid

Color

Yellow to orange

SMILES

O=C(CC(/C=C/C1=CC=C(O)C=C1)=O)/C=C/C2=CC=C(O)C(OC)=C2

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (295.55 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9555 mL	14.7776 mL	29.5552 mL
5 mM	0.5911 mL	2.9555 mL	5.9110 mL
10 mM	0.2956 mL	1.4778 mL	2.9555 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (266 KB) SDS (252 KB)

COA (243 KB) HNMR (217 KB)

Handling Instructions (2659 KB)

References

[1]. KOSUGE, T.,et al. Studies on active substances in the herbs used for Oketsu (“stagnant blood”) in Chinese medicine. III. On the anticoagulative principles in curcumae rhizoma. CHEMICAL & PHARMACEUTICAL BULLETIN, 1985;33(4):1499–1502.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9555 mL	14.7776 mL	29.5552 mL	73.8880 mL
	5 mM	0.5911 mL	2.9555 mL	5.9110 mL	14.7776 mL
	10 mM	0.2956 mL	1.4778 mL	2.9555 mL	7.3888 mL
	15 mM	0.1970 mL	0.9852 mL	1.9703 mL	4.9259 mL
	20 mM	0.1478 mL	0.7389 mL	1.4778 mL	3.6944 mL
	25 mM	0.1182 mL	0.5911 mL	1.1822 mL	2.9555 mL
	30 mM	0.0985 mL	0.4926 mL	0.9852 mL	2.4629 mL
	40 mM	0.0739 mL	0.3694 mL	0.7389 mL	1.8472 mL
	50 mM	0.0591 mL	0.2956 mL	0.5911 mL	1.4778 mL
	60 mM	0.0493 mL	0.2463 mL	0.4926 mL	1.2315 mL
	80 mM	0.0369 mL	0.1847 mL	0.3694 mL	0.9236 mL
	100 mM	0.0296 mL	0.1478 mL	0.2956 mL	0.7389 mL

(E/Z)-Demethoxycurcumin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E/Z)-Demethoxycurcumin24939-17-1p-Hydroxycinnamoyl-feruloylmethaneOthersInhibitorinhibitorinhibit

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(E/Z)-Demethoxycurcumin (Synonyms: p-Hydroxycinnamoyl-feruloylmethane)

Customer Review

Other Forms of (E/Z)-Demethoxycurcumin:

(E/Z)-Demethoxycurcumin Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

(E/Z)-Demethoxycurcumin Related Classifications

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SAFETY DATA SHEET (SDS)

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