2. PROTAC
  3. Ligands for E3 Ligase
  4. E3 ligase Ligand 32

E3 ligase Ligand 32 (First product in Example 52) is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 32 can be connected to the ligand for protein by a linker to form PROTACs and can be used for the synthesis of PROTAC SMARCA2/4-degrader-29 (HY-162743).

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E3 ligase Ligand 32 Chemical Structure

E3 ligase Ligand 32 Chemical Structure

CAS No. : 2300099-98-1

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E3 ligase Ligand 32 Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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Description

E3 ligase Ligand 32 (First product in Example 52) is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 32 can be connected to the ligand for protein by a linker to form PROTACs and can be used for the synthesis of PROTAC SMARCA2/4-degrader-29 (HY-162743)[1].

Molecular Weight

338.16

Formula

C13H12BrN3O3
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

O=C1NC(=O)C(CC1)N2C3=C(C=C(Br)C=C3)N(C)C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (295.72 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9572 mL 14.7859 mL 29.5718 mL
5 mM 0.5914 mL 2.9572 mL 5.9144 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.95%

SDS (393 KB)

COA (256 KB) HNMR (116 KB) RP-HPLC (224 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9572 mL 14.7859 mL 29.5718 mL 73.9295 mL
5 mM 0.5914 mL 2.9572 mL 5.9144 mL 14.7859 mL
10 mM 0.2957 mL 1.4786 mL 2.9572 mL 7.3930 mL
15 mM 0.1971 mL 0.9857 mL 1.9715 mL 4.9286 mL
20 mM 0.1479 mL 0.7393 mL 1.4786 mL 3.6965 mL
25 mM 0.1183 mL 0.5914 mL 1.1829 mL 2.9572 mL
30 mM 0.0986 mL 0.4929 mL 0.9857 mL 2.4643 mL
40 mM 0.0739 mL 0.3696 mL 0.7393 mL 1.8482 mL
50 mM 0.0591 mL 0.2957 mL 0.5914 mL 1.4786 mL
60 mM 0.0493 mL 0.2464 mL 0.4929 mL 1.2322 mL
80 mM 0.0370 mL 0.1848 mL 0.3696 mL 0.9241 mL
100 mM 0.0296 mL 0.1479 mL 0.2957 mL 0.7393 mL
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E3 ligase Ligand 32 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E3 ligase Ligand 322300099-98-1Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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