Pomalidomide-PEG3-C2-NH2 TFA (Synonyms: Cereblon Ligand-Linker Conjugates 5 TFA; E3 ligase Ligand-Linker Conjugates 30 TFA)

Name: Pomalidomide-PEG3-C2-NH2 TFA
Brand: MedChemExpress
SKU: HY-128716A
Rating: 4.5 (1 reviews)

Cat. No.: HY-128716A Purity: 99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Pomalidomide-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 5 (TFA)) is a synthetic E3 ligase ligand-linker conjugate comprising a Pomalidomide (HY-10984)-based cereblon ligand and a 3-unit PEG linker. Pomalidomide-PEG3-C2-NH2 TFA can be used for the synthesis of PROTACs.

For research use only. We do not sell to patients.

Pomalidomide-PEG3-C2-NH2 TFA Chemical Structure

CAS No. : 2414913-97-4

Size	Price	Stock	Quantity
50 mg	USD 219	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 1350	In-stock	Estimated Time of Arrival: December 31
1 g	USD 2500	In-stock	Estimated Time of Arrival: December 31
2 g	USD 3500	In-stock	Estimated Time of Arrival: December 31
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10 g		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Pomalidomide-PEG3-C2-NH2 TFA:

Pomalidomide-PEG3-C2-NH2 Get quote
Pomalidomide-PEG3-C2-NH2 hydrochloride Get quote

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Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

Cereblon

Molecular Weight

562.49

Formula

C₂₃H₂₉F₃N₄O₉

CAS No.

2414913-97-4

Appearance

Oil

Color

Light yellow to yellow

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCN)=O.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (177.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 100 mg/mL (177.78 mM; Need ultrasonic)

H₂O : 16.67 mg/mL (29.64 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7778 mL	8.8890 mL	17.7781 mL
5 mM	0.3556 mL	1.7778 mL	3.5556 mL
10 mM	0.1778 mL	0.8889 mL	1.7778 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.44 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.44 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.44 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 33.33 mg/mL (59.25 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.0%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (248 KB) HNMR (184 KB) LCMS (115 KB)

Handling Instructions (2659 KB)

References

[1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62(2):448-466. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO / Ethanol	1 mM	1.7778 mL	8.8890 mL	17.7781 mL	44.4452 mL
	5 mM	0.3556 mL	1.7778 mL	3.5556 mL	8.8890 mL
	10 mM	0.1778 mL	0.8889 mL	1.7778 mL	4.4445 mL
	15 mM	0.1185 mL	0.5926 mL	1.1852 mL	2.9630 mL
	20 mM	0.0889 mL	0.4445 mL	0.8889 mL	2.2223 mL
	25 mM	0.0711 mL	0.3556 mL	0.7111 mL	1.7778 mL
DMSO / Ethanol	30 mM	0.0593 mL	0.2963 mL	0.5926 mL	1.4815 mL
	40 mM	0.0444 mL	0.2222 mL	0.4445 mL	1.1111 mL
	50 mM	0.0356 mL	0.1778 mL	0.3556 mL	0.8889 mL
	60 mM	0.0296 mL	0.1482 mL	0.2963 mL	0.7408 mL
	80 mM	0.0222 mL	0.1111 mL	0.2222 mL	0.5556 mL
	100 mM	0.0178 mL	0.0889 mL	0.1778 mL	0.4445 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Pomalidomide-PEG3-C2-NH2 TFA Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-PEG3-C2-NH22414913-97-4Cereblon Ligand-Linker Conjugates 5E3 ligase Ligand-Linker Conjugates 30E3 Ligase Ligand-Linker ConjugatesPROTACpomalidomidecancerPEGInhibitorinhibitorinhibit

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Pomalidomide-PEG3-C2-NH2 TFA (Synonyms: Cereblon Ligand-Linker Conjugates 5 TFA; E3 ligase Ligand-Linker Conjugates 30 TFA)

Customer Review

Other Forms of Pomalidomide-PEG3-C2-NH2 TFA:

Pomalidomide-PEG3-C2-NH2 TFA Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Pomalidomide-PEG3-C2-NH2 TFA Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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