EBNA1-IN-SC7

Name: EBNA1-IN-SC7
Brand: MedChemExpress
SKU: HY-131236
Rating: 4.5 (1 reviews)

Cat. No.: HY-131236 Purity: 99.92%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

EBNA1-IN-SC7 (compound SC7) is a selective Epstein-Barr nuclear antigen 1 (EBNA1) inhibitor that interferes with EBNA1-DNA binding activity with an IC₅₀ value of 23 μM. EBNA1-IN-SC7 is used in EBV (Epstein-Barr virus)-related cancer research.

For research use only. We do not sell to patients.

EBNA1-IN-SC7 Chemical Structure

CAS No. : 324022-08-4

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 149	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 149	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 135	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 440	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 700	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1100	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

In Vitro

EBNA1-IN-SC7 (compound SC7) (5 µM) can completely block transcriptional activation of EBNA1 and show a 60% inhibition of Zta (EBV-encoded b-zip DNA binding protein) trans-activation in HEK293T cells^[2].
EBNA1-IN-SC7 (compound SC7) (10 µM, 6 days) has no significant effect on EBV genome copy number of Raji Burkitt lymphoma cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

462.31

Formula

C₂₀H₁₆BrNO₅S

CAS No.

324022-08-4

Appearance

Solid

Color

White to light yellow

SMILES

CC(N(C1=CC=C(OC(C)=O)C(Br)=C1)S(=O)(C2=CC=C3C=CC=CC3=C2)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (216.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1631 mL	10.8153 mL	21.6305 mL
5 mM	0.4326 mL	2.1631 mL	4.3261 mL
10 mM	0.2163 mL	1.0815 mL	2.1631 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.41 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (5.41 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.41 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (278 KB) SDS (393 KB)

COA (255 KB) HNMR (275 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Lijun Jiang, et al. EBNA1-targeted inhibitors: Novel approaches for the treatment of Epstein-Barr virus-associated cancers. Theranostics. 2018 Oct 22;8(19):5307-5319. [Content Brief]

[2]. Ning Li, et al. Discovery of selective inhibitors against EBNA1 via high throughput in silico virtual screening. PLoS One. 2010 Apr 12;5(4):e10126. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1631 mL	10.8153 mL	21.6305 mL	54.0763 mL
	5 mM	0.4326 mL	2.1631 mL	4.3261 mL	10.8153 mL
	10 mM	0.2163 mL	1.0815 mL	2.1631 mL	5.4076 mL
	15 mM	0.1442 mL	0.7210 mL	1.4420 mL	3.6051 mL
	20 mM	0.1082 mL	0.5408 mL	1.0815 mL	2.7038 mL
	25 mM	0.0865 mL	0.4326 mL	0.8652 mL	2.1631 mL
	30 mM	0.0721 mL	0.3605 mL	0.7210 mL	1.8025 mL
	40 mM	0.0541 mL	0.2704 mL	0.5408 mL	1.3519 mL
	50 mM	0.0433 mL	0.2163 mL	0.4326 mL	1.0815 mL
	60 mM	0.0361 mL	0.1803 mL	0.3605 mL	0.9013 mL
	80 mM	0.0270 mL	0.1352 mL	0.2704 mL	0.6760 mL
	100 mM	0.0216 mL	0.1082 mL	0.2163 mL	0.5408 mL

EBNA1-IN-SC7 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EBNA1-IN-SC7324022-08-4EBVEpstein-Barr VirusEBNA1EBV-associated cancersInhibitorinhibitorinhibit

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EBNA1-IN-SC7

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Complete Stock Solution Preparation Table

EBNA1-IN-SC7 Related Classifications

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