Ecamsule disodium

Name: Ecamsule disodium
Brand: MedChemExpress
SKU: HY-16182A
Rating: 4.5 (1 reviews)

Cat. No.: HY-16182A Purity: 99.88%: FAQs
Data Sheet SDS COA Handling Instructions

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Ecamsule disodium is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression.

For research use only. We do not sell to patients.

Ecamsule disodium Chemical Structure

CAS No. : 90458-75-6

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500 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Ecamsule disodium:

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Ecamsule is a broad-spectrum UVA-absorber with maximum absorbance at 344 nm^[1].
Wild-type Fibs E6/E7 cells are more sensitive towards Ecamsule (200-1600 μM) treatment^[1].
. Ecamsule counteractes UV and AAPH induced ROS-formation^[1].
. The effects are dose-dependent, reaching a maxi-mum ROS reduction by 25.7% at the highest tested concentration of 1600 μM in the UV-setting. With the same concentration of Ecamsule, oxidative stress that had been trigged by AAPH is reduced by 10.8% and basal levels are attenuated by 16.9%^[1].
. Ecamsule increases the viability at the highest applied concentration of 1600 μM in the AAPH-treated cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

606.66

Formula

C₂₈H₃₂Na₂O₈S₂

CAS No.

90458-75-6

Appearance

Solid

Color

White to off-white

SMILES

O=[S](CC(C1=O)(CCC2/C1=C/C(C=C3)=CC=C3/C=C(C4=O)/C(CCC45C[S](=O)(O[Na])=O)C5(C)C)C2(C)C)(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (82.42 mM; ultrasonic and warming and heat to 60°C)

DMSO : 50 mg/mL (82.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6484 mL	8.2418 mL	16.4837 mL
5 mM	0.3297 mL	1.6484 mL	3.2967 mL
10 mM	0.1648 mL	0.8242 mL	1.6484 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.12 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.12 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.12 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.88%

Select Batch:

Data Sheet (283 KB) SDS (393 KB)

COA (262 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Stefanie Hofer, et al. Contradictory effects of chemical filters in UV/ROS-stressed human keratinocyte and fibroblast cells. ALTEX. 2019;36(2):231-244. [Content Brief]

[2]. Vincent A DeLeo, et al. A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions. Cutis. 2009 Feb;83(2):95-103. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.6484 mL	8.2418 mL	16.4837 mL	41.2092 mL
	5 mM	0.3297 mL	1.6484 mL	3.2967 mL	8.2418 mL
	10 mM	0.1648 mL	0.8242 mL	1.6484 mL	4.1209 mL
	15 mM	0.1099 mL	0.5495 mL	1.0989 mL	2.7473 mL
	20 mM	0.0824 mL	0.4121 mL	0.8242 mL	2.0605 mL
	25 mM	0.0659 mL	0.3297 mL	0.6593 mL	1.6484 mL
	30 mM	0.0549 mL	0.2747 mL	0.5495 mL	1.3736 mL
	40 mM	0.0412 mL	0.2060 mL	0.4121 mL	1.0302 mL
	50 mM	0.0330 mL	0.1648 mL	0.3297 mL	0.8242 mL
	60 mM	0.0275 mL	0.1374 mL	0.2747 mL	0.6868 mL
	80 mM	0.0206 mL	0.1030 mL	0.2060 mL	0.5151 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.