2. Anti-infection
  3. Bacterial
  4. EGCG Octaacetate

EGCG Octaacetate  (Synonyms: AcEGCG; Peracetylated (-)-epigallocatechin-3-gallate)

Cat. No.: HY-N6263 Purity: 99.90%
SDS COA Handling Instructions

Molarity Calculator

EGCG Octaacetate (AcEGCG) is a proagent of Green tea epigallocatechin-3-gallate (EGCG). EGCG Octaacetate decreases the proinflammatory mediator levels by down-regulating of PI3K/Akt/NFκB phosphorylation and p65 acetylation. EGCG Octaacetate reduces colitis-driven colon cancer in mice. EGCG octaacetate is the potential antibacterial compound for gram-positive bacteria (GPB) and gram-negative bacteria (GNB).

For research use only. We do not sell to patients.

EGCG Octaacetate Chemical Structure

EGCG Octaacetate Chemical Structure

CAS No. : 148707-39-5

Size Price Stock Quantity
1 mg USD 84 In-stock
5 mg USD 178 In-stock
10 mg USD 303 In-stock
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Based on 1 publication(s) in Google Scholar

EGCG Octaacetate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE EGCG Octaacetate

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

EGCG Octaacetate (AcEGCG) is a proagent of Green tea epigallocatechin-3-gallate (EGCG). EGCG Octaacetate decreases the proinflammatory mediator levels by down-regulating of PI3K/Akt/NFκB phosphorylation and p65 acetylation. EGCG Octaacetate reduces colitis-driven colon cancer in mice. EGCG octaacetate is the potential antibacterial compound for gram-positive bacteria (GPB) and gram-negative bacteria (GNB)[1][2][3].

Cellular Effect
Cell Line Type Value Description References
L929 IC50
41.4 μM
Compound: peracetyl EGCG
Cytotoxicity against mouse L929 cells after 3 days by MTS assay
Cytotoxicity against mouse L929 cells after 3 days by MTS assay
[PMID: 25985195]
Molecular Weight

794.67

Formula

C38H34O19
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(OC(C)=O)=C(C(OC(C)=O)=C1)OC(C)=O)O[C@H]2[C@](C3=CC(OC(C)=O)=C(C(OC(C)=O)=C3)OC(C)=O)([H])OC4=CC(OC(C)=O)=CC(OC(C)=O)=C4C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (125.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2584 mL 6.2919 mL 12.5838 mL
5 mM 0.2517 mL 1.2584 mL 2.5168 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (3.15 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.90%

SDS (252 KB)

COA (261 KB) HNMR (299 KB) LCMS (269 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2584 mL 6.2919 mL 12.5838 mL 31.4596 mL
5 mM 0.2517 mL 1.2584 mL 2.5168 mL 6.2919 mL
10 mM 0.1258 mL 0.6292 mL 1.2584 mL 3.1460 mL
15 mM 0.0839 mL 0.4195 mL 0.8389 mL 2.0973 mL
20 mM 0.0629 mL 0.3146 mL 0.6292 mL 1.5730 mL
25 mM 0.0503 mL 0.2517 mL 0.5034 mL 1.2584 mL
30 mM 0.0419 mL 0.2097 mL 0.4195 mL 1.0487 mL
40 mM 0.0315 mL 0.1573 mL 0.3146 mL 0.7865 mL
50 mM 0.0252 mL 0.1258 mL 0.2517 mL 0.6292 mL
60 mM 0.0210 mL 0.1049 mL 0.2097 mL 0.5243 mL
80 mM 0.0157 mL 0.0786 mL 0.1573 mL 0.3932 mL
100 mM 0.0126 mL 0.0629 mL 0.1258 mL 0.3146 mL
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EGCG Octaacetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGCG Octaacetate148707-39-5AcEGCG Peracetylated (-)-epigallocatechin-3-gallateBacterialprodrugPI3K/Akt/NFκB phosphorylationp65 acetylationcolitis-driven colon cancergram-positive bacteriagram-negative bacteriaInhibitorinhibitorinhibit

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