2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR-IN-70

EGFR-IN-70 (compound 18j) is a potent EGFR inhibitor with IC50 values of 23.6 and 307.5 nM for EGFRLR/TM/CS and EGFRWT, respectively. EGFR-IN-70 has anti-proliferative activity and suppresses phosphorylation of the EGFR. EGFR-IN-70 can be used for cancer research.

For research use only. We do not sell to patients.

EGFR-IN-70 Chemical Structure

EGFR-IN-70 Chemical Structure

CAS No. : 2926716-96-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 661 In-stock
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10 mM * 1 mL in DMSO USD 661 In-stock
Solid
5 mg USD 480 In-stock
10 mg USD 800 In-stock
25 mg USD 1650 In-stock
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Based on 1 publication(s) in Google Scholar

EGFR-IN-70 Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • Biological Activity

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Description

EGFR-IN-70 (compound 18j) is a potent EGFR inhibitor with IC50 values of 23.6 and 307.5 nM for EGFRLR/TM/CS and EGFRWT, respectively. EGFR-IN-70 has anti-proliferative activity and suppresses phosphorylation of the EGFR. EGFR-IN-70 can be used for cancer research[1].

IC50 & Target

IC50: 23.6 nM (EGFRLR/TM/CS) and 307.5 nM EGFRWT)[1]
In Vitro

EGFR-IN-70 (compound 18j) (72 hours) has anti-proliferative activity and suppresses the proliferation of Ba/F3-EGFR19del/TM/CS, PC-9-OR-EGFR19del/TM/CS and A431- EGFRWT cells with IC50 values of 0.052, 0.644 and 2.003 μM, respectively[1].
EGFR-IN-70 (compound 18j) (0-1000 nM; 2 hours; Ba/F3-EGFR19del/TM/CS and PC-9-OR-EGFR19del/TM/CS cells) can suppresse phosphorylation of the EGFR[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-70 Related Antibodies

Western Blot Analysis[1]

Cell Line: Ba/F3-EGFR19del/TM/CS and PC-9-OR-EGFR19del/TM/CS cells
Concentration: 1, 3, 10, 30, 100, 300 and 1000 nM
Incubation Time: 2 hours
Result: Suppressed phosphorylation of the EGFR and the downstream signaling ERK level.
Molecular Weight

626.17

Formula

C31H36ClN5O5S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=S(CC)(N1C2=CC(OCCCCCCOC3=CC(N4)=C(C)C=C3N5CCOCC5)=CC=C2C(C6=NC4=NC=C6Cl)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (159.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5970 mL 7.9851 mL 15.9701 mL
5 mM 0.3194 mL 1.5970 mL 3.1940 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5970 mL 7.9851 mL 15.9701 mL 39.9253 mL
5 mM 0.3194 mL 1.5970 mL 3.1940 mL 7.9851 mL
10 mM 0.1597 mL 0.7985 mL 1.5970 mL 3.9925 mL
15 mM 0.1065 mL 0.5323 mL 1.0647 mL 2.6617 mL
20 mM 0.0799 mL 0.3993 mL 0.7985 mL 1.9963 mL
25 mM 0.0639 mL 0.3194 mL 0.6388 mL 1.5970 mL
30 mM 0.0532 mL 0.2662 mL 0.5323 mL 1.3308 mL
40 mM 0.0399 mL 0.1996 mL 0.3993 mL 0.9981 mL
50 mM 0.0319 mL 0.1597 mL 0.3194 mL 0.7985 mL
60 mM 0.0266 mL 0.1331 mL 0.2662 mL 0.6654 mL
80 mM 0.0200 mL 0.0998 mL 0.1996 mL 0.4991 mL
100 mM 0.0160 mL 0.0799 mL 0.1597 mL 0.3993 mL
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EGFR-IN-70 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-702926716-96-1EGFREpidermal growth factor receptorErbB-1HER1anticancerphosphorylationEGFR LR/TM/CSEGFR WTInhibitorinhibitorinhibit

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