2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR Apoptosis
  4. EGFR-TK-IN-4

EGFR-TK-IN-4 (compound 10k) is a potent and selective EGFR-TK inhibitor. EGFR-TK-IN-4 can induce apoptosis . EGFR-TK-IN-4 has antitumor activity.

For research use only. We do not sell to patients.

EGFR-TK-IN-4 Chemical Structure

EGFR-TK-IN-4 Chemical Structure

CAS No. : 3053485-72-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO In-stock
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

EGFR-TK-IN-4 (compound 10k) is a potent and selective EGFR-TK inhibitor. EGFR-TK-IN-4 can induce apoptosis . EGFR-TK-IN-4 has antitumor activity[1].

Molecular Weight

510.54

Formula

C23H16F2N6O2S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=NC=C(C2=CN=C(SC(C3=CC=CC(NS(C4=CC(F)=CC=C4F)(=O)=O)=C3C)=N5)C5=C2)C=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (195.87 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9587 mL 9.7936 mL 19.5871 mL
5 mM 0.3917 mL 1.9587 mL 3.9174 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (4.90 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9587 mL 9.7936 mL 19.5871 mL 48.9678 mL
5 mM 0.3917 mL 1.9587 mL 3.9174 mL 9.7936 mL
10 mM 0.1959 mL 0.9794 mL 1.9587 mL 4.8968 mL
15 mM 0.1306 mL 0.6529 mL 1.3058 mL 3.2645 mL
20 mM 0.0979 mL 0.4897 mL 0.9794 mL 2.4484 mL
25 mM 0.0783 mL 0.3917 mL 0.7835 mL 1.9587 mL
30 mM 0.0653 mL 0.3265 mL 0.6529 mL 1.6323 mL
40 mM 0.0490 mL 0.2448 mL 0.4897 mL 1.2242 mL
50 mM 0.0392 mL 0.1959 mL 0.3917 mL 0.9794 mL
60 mM 0.0326 mL 0.1632 mL 0.3265 mL 0.8161 mL
80 mM 0.0245 mL 0.1224 mL 0.2448 mL 0.6121 mL
100 mM 0.0196 mL 0.0979 mL 0.1959 mL 0.4897 mL
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EGFR-TK-IN-4 Related Classifications

Keywords:

EGFR-TK-IN-43053485-72-3EGFRApoptosisEpidermal growth factor receptorErbB-1HER1InhibitorHCC827antitumorinhibitorinhibit

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