EGGGG-PEG8-amide-bis(deoxyglucitol)

Name: EGGGG-PEG8-amide-bis(deoxyglucitol)
Brand: MedChemExpress
SKU: HY-49484
Rating: 4.5 (1 reviews)

Cat. No.: HY-49484 Purity: 98.90%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

EGGGG-PEG8-amide-bis(deoxyglucitol) is a cleavable ADC linker.

For research use only. We do not sell to patients.

EGGGG-PEG8-amide-bis(deoxyglucitol) Chemical Structure

CAS No. : 2842855-38-1

Size	Price	Stock	Quantity
5 mg	USD 573	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 917	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1926	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 3082	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 4931	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
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Description

EGGGG-PEG8-amide-bis(deoxyglucitol) is a cleavable ADC linker.

Molecular Weight

1254.29

Formula

C₄₉H₉₁N₉O₂₈

CAS No.

2842855-38-1

Appearance

Solid-Liquid Mixture

Color

White to off-white

SMILES

O=C(O)CC[C@@H](C(NCC(NCC(NCC(NCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(N[C@H](C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)=O)CCC(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)=O)=O)=O)=O)=O)=O)=O)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 75 mg/mL (59.79 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7973 mL	3.9863 mL	7.9726 mL
5 mM	0.1595 mL	0.7973 mL	1.5945 mL
10 mM	0.0797 mL	0.3986 mL	0.7973 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 3.75 mg/mL (2.99 mM); Clear solution

This protocol yields a clear solution of ≥ 3.75 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (37.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 3.75 mg/mL (2.99 mM); Clear solution

This protocol yields a clear solution of ≥ 3.75 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (37.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 3.75 mg/mL (2.99 mM); Clear solution

This protocol yields a clear solution of ≥ 3.75 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (37.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.90%

Select Batch:

Data Sheet (241 KB) SDS (393 KB)

COA (245 KB) HNMR (439 KB) RP-HPLC (259 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7973 mL	3.9863 mL	7.9726 mL	19.9316 mL
	5 mM	0.1595 mL	0.7973 mL	1.5945 mL	3.9863 mL
	10 mM	0.0797 mL	0.3986 mL	0.7973 mL	1.9932 mL
	15 mM	0.0532 mL	0.2658 mL	0.5315 mL	1.3288 mL
	20 mM	0.0399 mL	0.1993 mL	0.3986 mL	0.9966 mL
	25 mM	0.0319 mL	0.1595 mL	0.3189 mL	0.7973 mL
	30 mM	0.0266 mL	0.1329 mL	0.2658 mL	0.6644 mL
	40 mM	0.0199 mL	0.0997 mL	0.1993 mL	0.4983 mL
	50 mM	0.0159 mL	0.0797 mL	0.1595 mL	0.3986 mL