2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. Eglumegad hydrochloride

Eglumegad hydrochloride  (Synonyms: LY354740 hydrochloride; Eglumetad hydrochloride)

Cat. No.: HY-18941C Purity: ≥95.0%
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Eglumegad (LY354740) hydrochloride is a highly potent and selective group II (mGlu2/3) receptor agonist with IC50s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively. Eglumegad hydrochloride protects neurons from NMDA toxicity. Eglumegad hydrochloride has anxiolytic- and antipsychotic-like effects.

For research use only. We do not sell to patients.

Eglumegad hydrochloride Chemical Structure

Eglumegad hydrochloride Chemical Structure

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5 mg USD 150 In-stock
10 mg USD 250 In-stock
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Based on 3 publication(s) in Google Scholar

Other Forms of Eglumegad hydrochloride:

Eglumegad hydrochloride Related Antibodies

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Description

Eglumegad (LY354740) hydrochloride is a highly potent and selective group II (mGlu2/3) receptor agonist with IC50s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively. Eglumegad hydrochloride protects neurons from NMDA toxicity. Eglumegad hydrochloride has anxiolytic- and antipsychotic-like effects[1].

Molecular Weight

221.64

Formula

C8H12ClNO4
Appearance

Solid

Color

White to off-white

SMILES

OC([C@]1([C@]2([H])[C@@H](C(O)=O)[C@]2([H])CC1)N)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 175 mg/mL (789.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5118 mL 22.5591 mL 45.1182 mL
5 mM 0.9024 mL 4.5118 mL 9.0236 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.5118 mL 22.5591 mL 45.1182 mL 112.7955 mL
5 mM 0.9024 mL 4.5118 mL 9.0236 mL 22.5591 mL
10 mM 0.4512 mL 2.2559 mL 4.5118 mL 11.2796 mL
15 mM 0.3008 mL 1.5039 mL 3.0079 mL 7.5197 mL
20 mM 0.2256 mL 1.1280 mL 2.2559 mL 5.6398 mL
25 mM 0.1805 mL 0.9024 mL 1.8047 mL 4.5118 mL
30 mM 0.1504 mL 0.7520 mL 1.5039 mL 3.7599 mL
40 mM 0.1128 mL 0.5640 mL 1.1280 mL 2.8199 mL
50 mM 0.0902 mL 0.4512 mL 0.9024 mL 2.2559 mL
60 mM 0.0752 mL 0.3760 mL 0.7520 mL 1.8799 mL
80 mM 0.0564 mL 0.2820 mL 0.5640 mL 1.4099 mL
100 mM 0.0451 mL 0.2256 mL 0.4512 mL 1.1280 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Eglumegad hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EglumegadLY354740EglumetadLY 354740LY-354740mGluRMetabotropic glutamate receptorsanxiolyticantipsychoticneurotoxicityNMDAInhibitorinhibitorinhibit

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