N,N-Dimethylsphingosine

Cat. No.: HY-108491 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

N,N-Dimethylsphingosine is a potent inhbitor of SphK (sphingosine kinase) as an endogenous metabolite of sphingosine produced in various tissues and tumor cell lines.

For research use only. We do not sell to patients.

N,N-Dimethylsphingosine Chemical Structure

CAS No. : 119567-63-4

Size	Stock	Quantity
Solvent
5 mg (76.32 mM * 200 μL in Ethanol)	In-stock	Estimated Time of Arrival: December 31
Solvent
10 mg (76.32 mM * 400 μL in Ethanol)	In-stock	Estimated Time of Arrival: December 31

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Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE N,N-Dimethylsphingosine

•J Adv Res. 2023 Oct 19:S2090-1232(23)00314-4. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

N,N-Dimethylsphingosine is a potent inhbitor of SphK (sphingosine kinase) as an endogenous metabolite of sphingosine produced in various tissues and tumor cell lines^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
FL5.12	IC₅₀	0.8 μM Compound: 8	Cytotoxicity against mouse FL5.12A cells after 48 hrs by DAPI staining-based flow cytometric analysis Cytotoxicity against mouse FL5.12A cells after 48 hrs by DAPI staining-based flow cytometric analysis	[PMID: 27475534]
RAW264.7	IC₅₀	2.3 μM Compound: N,N-Dimethylsphingosine	Protection against Bacillus anthracis lethal toxin-mediated cytotoxicity in mouse RAW264.7 cells assessed as change in viability after 24 hrs by WST1 dye reduction assay Protection against Bacillus anthracis lethal toxin-mediated cytotoxicity in mouse RAW264.7 cells assessed as change in viability after 24 hrs by WST1 dye reduction assay	[PMID: 17485504]

Molecular Weight

327.55

Formula

C₂₀H₄₁NO₂

CAS No.

119567-63-4

Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N(C)C)CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Solution, -20°C, 2 years

Purity & Documentation

Purity: ≥99.0%

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Data Sheet (261 KB) SDS (251 KB)

COA (239 KB)

Handling Instructions (2659 KB)

References

[1]. Endo K, et al. Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice. Cancer Res. [Content Brief]