2. Apoptosis Metabolic Enzyme/Protease
  3. Bcl-2 Family Cytochrome P450 Apoptosis Caspase
  4. EMT inhibitor-3

EMT inhibitor-3 (compound 11i) is a epithelial-mesenchymal transition (EMT) inhibitor. EMT inhibitor-3 inhibits neuroblastoma SK-N-SH cells with an IC50 of 2.5 μM. EMT inhibitor-3 inhibits SK-N-SH cell proliferation, migration, and invasion. EMT inhibitor-3 increases the Bax/Bcl-2 protein expression ratio, promotes Cytochrome C( HY-125857) release from mitochondria, and activates caspases 9 and caspases 3, inducing mitochondria-mediated endogenous tumor cell Apoptosis. EMT inhibitor-3 is potential for cancer research.

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EMT inhibitor-3 Chemical Structure

EMT inhibitor-3 Chemical Structure

CAS No. : 2930726-89-7

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EMT inhibitor-3 Related Antibodies

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

EMT inhibitor-3 (compound 11i) is a epithelial-mesenchymal transition (EMT) inhibitor. EMT inhibitor-3 inhibits neuroblastoma SK-N-SH cells with an IC50 of 2.5 μM. EMT inhibitor-3 inhibits SK-N-SH cell proliferation, migration, and invasion. EMT inhibitor-3 increases the Bax/Bcl-2 protein expression ratio, promotes Cytochrome C( HY-125857) release from mitochondria, and activates caspases 9 and caspases 3, inducing mitochondria-mediated endogenous tumor cell Apoptosis. EMT inhibitor-3 is potential for cancer research[1].

IC50 & Target[1]

Bax

 

Bcl-2

 

Caspase 3

 

Caspase 9

 

Molecular Weight

592.45

Formula

C29H21F2N3O4Se
CAS No.
SMILES

O=C1C(C(N2N=C(C3=CC=C(F)C=C3)CC2C4=CC=C(F)C=C4)=O)=CC5=C(O1)C=C(OCCC[Se]C#N)C=C5
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Purity & Documentation
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EMT inhibitor-3 Related Classifications

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Keywords:

EMT inhibitor-32930726-89-7EMT inhibitor3EMT inhibitor 3Bcl-2 FamilyCytochrome P450ApoptosisCaspaseCYPsmitochondriaanti-tumocell proliferationSK-N-SH cellsInhibitorinhibitorinhibit

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