2. Metabolic Enzyme/Protease
  3. Proteasome
  4. Enzyme-IN-1

Enzyme-IN-1 (compound 1) is a peptide-based inhibitor of N-terminal nucleophile (Ntn) hydrolases. Specifically, Enzyme-IN-1 inhibits the chymotrypsin-like activity (CT-L) of the 20S proteasome. Enzyme-IN-1 may has potential antiinflammatory properties.

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Enzyme-IN-1 Chemical Structure

Enzyme-IN-1 Chemical Structure

CAS No. : 868540-02-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Solid
1 mg USD 200 In-stock
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Based on 1 publication(s) in Google Scholar

Enzyme-IN-1 Related Antibodies

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Description

Enzyme-IN-1 (compound 1) is a peptide-based inhibitor of N-terminal nucleophile (Ntn) hydrolases. Specifically, Enzyme-IN-1 inhibits the chymotrypsin-like activity (CT-L) of the 20S proteasome. Enzyme-IN-1 may has potential antiinflammatory properties[1].

Molecular Weight

650.80

Formula

C36H50N4O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCC(N[C@@H](CCC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C([C@]3(CO3)C)=O)=O)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (76.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5366 mL 7.6829 mL 15.3657 mL
5 mM 0.3073 mL 1.5366 mL 3.0731 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5366 mL 7.6829 mL 15.3657 mL 38.4143 mL
5 mM 0.3073 mL 1.5366 mL 3.0731 mL 7.6829 mL
10 mM 0.1537 mL 0.7683 mL 1.5366 mL 3.8414 mL
15 mM 0.1024 mL 0.5122 mL 1.0244 mL 2.5610 mL
20 mM 0.0768 mL 0.3841 mL 0.7683 mL 1.9207 mL
25 mM 0.0615 mL 0.3073 mL 0.6146 mL 1.5366 mL
30 mM 0.0512 mL 0.2561 mL 0.5122 mL 1.2805 mL
40 mM 0.0384 mL 0.1921 mL 0.3841 mL 0.9604 mL
50 mM 0.0307 mL 0.1537 mL 0.3073 mL 0.7683 mL
60 mM 0.0256 mL 0.1280 mL 0.2561 mL 0.6402 mL
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Enzyme-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enzyme-IN-1868540-02-7ProteasomeInhibitorinhibitorinhibit

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