2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. EP3 antagonist 3

EP3 antagonist 3 (compound 2) is an orally active, potent and selective EP3 antagonist, with a pKi of 8.3. EP3 antagonist 3 shows excellent pharmacokinetic properties. EP3 antagonist 3 can be used for overactive bladder (OAB) research.

For research use only. We do not sell to patients.

EP3 antagonist 3 Chemical Structure

EP3 antagonist 3 Chemical Structure

CAS No. : 1227827-88-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 330 In-stock
Solution
10 mM * 1 mL in DMSO USD 330 In-stock
Solid
5 mg USD 300 In-stock
10 mg USD 450 In-stock
25 mg USD 950 In-stock
50 mg USD 1500 In-stock
100 mg USD 2400 In-stock
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Based on 1 publication(s) in Google Scholar

EP3 antagonist 3 Related Antibodies

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Description

EP3 antagonist 3 (compound 2) is an orally active, potent and selective EP3 antagonist, with a pKi of 8.3. EP3 antagonist 3 shows excellent pharmacokinetic properties. EP3 antagonist 3 can be used for overactive bladder (OAB) research[1].

IC50 & Target

EP3

8.3 (pKi)

Molecular Weight

362.38

Formula

C21H18N2O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1OC(C2=CC=C(C3=CC4=C(C=CC=C4)C=C3)NC2=O)(C(C)C)C(N1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (689.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7595 mL 13.7977 mL 27.5953 mL
5 mM 0.5519 mL 2.7595 mL 5.5191 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7595 mL 13.7977 mL 27.5953 mL 68.9884 mL
5 mM 0.5519 mL 2.7595 mL 5.5191 mL 13.7977 mL
10 mM 0.2760 mL 1.3798 mL 2.7595 mL 6.8988 mL
15 mM 0.1840 mL 0.9198 mL 1.8397 mL 4.5992 mL
20 mM 0.1380 mL 0.6899 mL 1.3798 mL 3.4494 mL
25 mM 0.1104 mL 0.5519 mL 1.1038 mL 2.7595 mL
30 mM 0.0920 mL 0.4599 mL 0.9198 mL 2.2996 mL
40 mM 0.0690 mL 0.3449 mL 0.6899 mL 1.7247 mL
50 mM 0.0552 mL 0.2760 mL 0.5519 mL 1.3798 mL
60 mM 0.0460 mL 0.2300 mL 0.4599 mL 1.1498 mL
80 mM 0.0345 mL 0.1725 mL 0.3449 mL 0.8624 mL
100 mM 0.0276 mL 0.1380 mL 0.2760 mL 0.6899 mL
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EP3 antagonist 3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EP3 antagonist 31227827-88-4Prostaglandin Receptoroveractive bladderEP3 receptororally activeantagonists3-oxazolidinedione-6-aryl-pyridinonesInhibitorinhibitorinhibit

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