2. Protein Tyrosine Kinase/RTK
  3. Ephrin Receptor
  4. EphA2 agonist 1

EphA2 agonist 1 (Compound 7bg) is a potent EphA2 receptor agonist. EphA2 agonist 1 shows great potency and selectivity toward EphA2 overexpressed glioblastoma cells and stimulates EphA2 phosphorylation.

For research use only. We do not sell to patients.

EphA2 agonist 1 Chemical Structure

EphA2 agonist 1 Chemical Structure

CAS No. : 2611459-57-3

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10 mg USD 1040 In-stock
25 mg USD 2080 In-stock
50 mg USD 3328 In-stock
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Based on 1 publication(s) in Google Scholar

EphA2 agonist 1 Related Antibodies

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Description

EphA2 agonist 1 (Compound 7bg) is a potent EphA2 receptor agonist. EphA2 agonist 1 shows great potency and selectivity toward EphA2 overexpressed glioblastoma cells and stimulates EphA2 phosphorylation[1].

IC50 & Target

EphA2[1]
In Vitro

EphA2 agonist 1 (Compound 7bg) inhibits cell proliferation with IC50 values of 1.90 ± 0.55 μM and 7.91 ± 2.28 μM against U251 EphA2 overexpressed and U251 wild type cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EphA2 agonist 1 Related Antibodies
Molecular Weight

1019.07

Formula

C50H58N12O12
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=C(C=C2C(N=C(N=C2N)N3CCN(CC3)C(C4=CC(NC(OCCOCCOCCOC(NC5=CC=CC(C(N6CCN(CC6)C7=NC8=CC(OC)=C(C=C8C(N)=N7)OC)=O)=C5)=O)=O)=CC=C4)=O)=C1)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (49.06 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9813 mL 4.9064 mL 9.8129 mL
5 mM 0.1963 mL 0.9813 mL 1.9626 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9813 mL 4.9064 mL 9.8129 mL 24.5322 mL
5 mM 0.1963 mL 0.9813 mL 1.9626 mL 4.9064 mL
10 mM 0.0981 mL 0.4906 mL 0.9813 mL 2.4532 mL
15 mM 0.0654 mL 0.3271 mL 0.6542 mL 1.6355 mL
20 mM 0.0491 mL 0.2453 mL 0.4906 mL 1.2266 mL
25 mM 0.0393 mL 0.1963 mL 0.3925 mL 0.9813 mL
30 mM 0.0327 mL 0.1635 mL 0.3271 mL 0.8177 mL
40 mM 0.0245 mL 0.1227 mL 0.2453 mL 0.6133 mL
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EphA2 agonist 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EphA2 agonist 12611459-57-3Ephrin ReceptorglioblastomaU251Inhibitorinhibitorinhibit

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