2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. EPI-X4

EPI-X4  (Synonyms: hSA(408–423) peptide)

Cat. No.: HY-P10415 Purity: 98.80%
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EPI-X4 (hSA408–423 peptide) is an antagonist for C-X-C motif chemokine receptor 4 (CXCR4) with IC50 of 8.6 μM. EPI-X4 blocks the CXCL12-mediated signaling, inhibits chemokine-mediated migration and invasion of leukemia cell. EPI-X4 exhibits anti-inflammatory activity in mouse model. EPI-X4 exhibits antiviral activity against CXCR4-tropic HIV with IC50 of 8.6 μM.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

EPI-X4 Chemical Structure

EPI-X4 Chemical Structure

CAS No. : 930280-31-2

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Based on 1 publication(s) in Google Scholar

EPI-X4 Related Antibodies

Top Publications Citing Use of Products

View All CXCR Isoform Specific Products:

View All Isoforms
CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6

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Description

EPI-X4 (hSA408–423 peptide) is an antagonist for C-X-C motif chemokine receptor 4 (CXCR4) with IC50 of 8.6 μM. EPI-X4 blocks the CXCL12-mediated signaling, inhibits chemokine-mediated migration and invasion of leukemia cell. EPI-X4 exhibits anti-inflammatory activity in mouse model. EPI-X4 exhibits antiviral activity against CXCR4-tropic HIV with IC50 of 8.6 μM[1].

IC50 & Target

CXCR4

8.6 μM (IC50)

Molecular Weight

1830.18

Formula

C84H144N22O23
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Leu-Val-Arg-Tyr-Thr-Lys-Lys-Val-Pro-Gln-Val-Ser-Thr-Pro-Thr-Leu
Sequence Shortening

LVRYTKKVPQVSTPTL
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (54.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5464 mL 2.7320 mL 5.4639 mL
5 mM 0.1093 mL 0.5464 mL 1.0928 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5464 mL 2.7320 mL 5.4639 mL 13.6599 mL
5 mM 0.1093 mL 0.5464 mL 1.0928 mL 2.7320 mL
10 mM 0.0546 mL 0.2732 mL 0.5464 mL 1.3660 mL
15 mM 0.0364 mL 0.1821 mL 0.3643 mL 0.9107 mL
20 mM 0.0273 mL 0.1366 mL 0.2732 mL 0.6830 mL
25 mM 0.0219 mL 0.1093 mL 0.2186 mL 0.5464 mL
30 mM 0.0182 mL 0.0911 mL 0.1821 mL 0.4553 mL
40 mM 0.0137 mL 0.0683 mL 0.1366 mL 0.3415 mL
50 mM 0.0109 mL 0.0546 mL 0.1093 mL 0.2732 mL
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EPI-X4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EPI-X4930280-31-2hSA(408–423) peptideCXCRCXC chemokine receptorsC-X-C motif chemokine receptorsDU145Jurkatatopic dermatitisasthmaleukemiaC57BL/6 mouseInhibitorinhibitorinhibit

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