2. Metabolic Enzyme/Protease
  3. Factor Xa
  4. Eribaxaban

Eribaxaban  (Synonyms: PD-0348292)

Cat. No.: HY-10267 Purity: 98.52%
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Eribaxaban (PD-0348292) is an orally active and selective FXa inhibitor with a Ki value of 0.32 nM. Eribaxaban reduces thrombus formation.

For research use only. We do not sell to patients.

Eribaxaban Chemical Structure

Eribaxaban Chemical Structure

CAS No. : 536748-46-6

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5 mg USD 110 In-stock
10 mg USD 175 In-stock
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Based on 1 publication(s) in Google Scholar

Eribaxaban Related Antibodies

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Description

Eribaxaban (PD-0348292) is an orally active and selective FXa inhibitor with a Ki value of 0.32 nM. Eribaxaban reduces thrombus formation[1][2].

IC50 & Target

Ki: 0.32 nM (FXa)[1]
In Vivo

Eribaxaban (0.4, 0.9, 4.3 mg/kg; p.o.) reduces platelet-rich thrombus formation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Four-month-old, pre-estrus, female pigs[2]
Dosage: 0.4, 0.9, 4.3 mg/kg
Administration: P.o.; four hours prior to thrombus induction
Result: Significantly reducted carotid platelet deposition, chamber platelet deposition.
Molecular Weight

484.91

Formula

C24H22ClFN4O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC(C=C1)=CC=C1Cl)N2[C@H](C[C@@H](OC)C2)C(NC3=CC=C(C=C3F)N(C=CC=C4)C4=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (257.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0622 mL 10.3112 mL 20.6224 mL
5 mM 0.4124 mL 2.0622 mL 4.1245 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0622 mL 10.3112 mL 20.6224 mL 51.5560 mL
5 mM 0.4124 mL 2.0622 mL 4.1245 mL 10.3112 mL
10 mM 0.2062 mL 1.0311 mL 2.0622 mL 5.1556 mL
15 mM 0.1375 mL 0.6874 mL 1.3748 mL 3.4371 mL
20 mM 0.1031 mL 0.5156 mL 1.0311 mL 2.5778 mL
25 mM 0.0825 mL 0.4124 mL 0.8249 mL 2.0622 mL
30 mM 0.0687 mL 0.3437 mL 0.6874 mL 1.7185 mL
40 mM 0.0516 mL 0.2578 mL 0.5156 mL 1.2889 mL
50 mM 0.0412 mL 0.2062 mL 0.4124 mL 1.0311 mL
60 mM 0.0344 mL 0.1719 mL 0.3437 mL 0.8593 mL
80 mM 0.0258 mL 0.1289 mL 0.2578 mL 0.6444 mL
100 mM 0.0206 mL 0.1031 mL 0.2062 mL 0.5156 mL
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Eribaxaban Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eribaxaban536748-46-6PD-0348292PD0348292PD 0348292Factor XaFxaorally activethrombus formationarterial thrombosisInhibitorinhibitorinhibit

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