Estradiol-d₅ (Synonyms: β-Estradiol-d₅; 17β-Estradiol-d₅; 17β-Oestradiol-d₅)

Name: Estradiol-d 5
Brand: MedChemExpress
SKU: HY-B0141S2
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0141S2 Purity: 99.88%: FAQs
Data Sheet SDS COA Handling Instructions

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Estradiol-d₅ is deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

For research use only. We do not sell to patients.

Estradiol-d<sub>5</sub> Chemical Structure

Estradiol-d₅ Chemical Structure

CAS No. : 221093-45-4

Size	Price	Stock	Quantity
1 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 380	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Estradiol-d₅:

Estradiol In-stock
Estradiol-d₄ Get quote
rel-Estradiol-¹³C₆ Get quote

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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

277.41

Formula

C₁₈H₁₉D₅O₂

CAS No.

221093-45-4

Unlabeled CAS

50-28-2

Appearance

Solid

Color

White to off-white

SMILES

C[C@]1(CC2)[C@](CC([2H])([2H])[C@]1([2H])O)([H])[C@@](CCC3=C4[2H])([H])[C@@]2([H])C3=CC([2H])=C4O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Ethanol : 20 mg/mL (72.10 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6048 mL	18.0239 mL	36.0477 mL
5 mM	0.7210 mL	3.6048 mL	7.2095 mL
10 mM	0.3605 mL	1.8024 mL	3.6048 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.88%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (253 KB) HNMR (231 KB) RP-HPLC (513 KB)

Handling Instructions (2659 KB)

References

[1]. Harburger LL, et al. Dose-dependent effects of post-training estradiol plus progesterone treatment on object memory consolidation and hippocampal extracellular signal-regulated kinase activation in young ovariectomized mice. Neuroscience. 2009;160(1):6-12. [Content Brief]

[2]. Mermelstein PG, et al. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci. 1996 Jan 15;16(2):595-604. [Content Brief]

[3]. Quanfu Huang, et al. 17β-estradiol Upregulates IL6 Expression Through the ERβ Pathway to Promote Lung Adenocarcinoma Progression. J Exp Clin Cancer Res. 2018 Jul 3;37(1):133. [Content Brief]

[4]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[5]. Woolley CS, et al. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci. 1997 Mar 1;17(5):1848-59. [Content Brief]

[6]. Woolley CS, et al. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992 Jul;12(7):2549-54. [Content Brief]

[7]. Woolley CS, et al. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol. 1993 Oct 8;336(2):293-306. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol / Ethanol	1 mM	3.6048 mL	18.0239 mL	36.0477 mL	90.1193 mL
	5 mM	0.7210 mL	3.6048 mL	7.2095 mL	18.0239 mL
	10 mM	0.3605 mL	1.8024 mL	3.6048 mL	9.0119 mL
	15 mM	0.2403 mL	1.2016 mL	2.4032 mL	6.0080 mL
	20 mM	0.1802 mL	0.9012 mL	1.8024 mL	4.5060 mL
	25 mM	0.1442 mL	0.7210 mL	1.4419 mL	3.6048 mL
	30 mM	0.1202 mL	0.6008 mL	1.2016 mL	3.0040 mL
	40 mM	0.0901 mL	0.4506 mL	0.9012 mL	2.2530 mL
	50 mM	0.0721 mL	0.3605 mL	0.7210 mL	1.8024 mL
	60 mM	0.0601 mL	0.3004 mL	0.6008 mL	1.5020 mL

Estradiol-d₅ Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Estradiol-d₅221093-45-4β-Estradiol-d₅17β-Estradiol-d₅17β-Oestradiol-d₅Estrogen Receptor/ERREndogenous MetaboliteInhibitorinhibitorinhibit

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Estradiol-d5 (Synonyms: β-Estradiol-d5; 17β-Estradiol-d5; 17β-Oestradiol-d5)

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Complete Stock Solution Preparation Table

Estradiol-d5 Related Classifications

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Estradiol-d₅ (Synonyms: β-Estradiol-d₅; 17β-Estradiol-d₅; 17β-Oestradiol-d₅)

Other Forms of Estradiol-d₅:

Estradiol-d₅ Related Antibodies

Estradiol-d₅ Related Antibodies

Estradiol-d₅ Related Classifications