2. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Estrogen Receptor/ERR Endogenous Metabolite
  4. Ethynyl Estradiol-d4

Ethynyl Estradiol-d4  (Synonyms: 17α-Ethynylestradiol-d4; Ethynylestradiol-d4)

Cat. No.: HY-B0216S Purity: 97.31%
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Ethynyl Estradiol-d4 is the deuterium labeled Ethynyl Estradiol. Ethynyl Estradiol (17α-Ethynylestradiol;Ethynylestradiol) is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills. Ethynyl Estradiol-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Ethynyl Estradiol-d<sub>4</sub> Chemical Structure

Ethynyl Estradiol-d4 Chemical Structure

CAS No. : 350820-06-3

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5 mg USD 2050 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Ethynyl Estradiol-d4:

Ethynyl Estradiol-d4 Related Antibodies

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Description

Ethynyl Estradiol-d4 is the deuterium labeled Ethynyl Estradiol. Ethynyl Estradiol (17α-Ethynylestradiol;Ethynylestradiol) is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills. Ethynyl Estradiol-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ethynyl Estradiol-d4 Related Antibodies
Molecular Weight

300.43

Formula

C20H20D4O2
CAS No.
Unlabeled CAS

57-63-6
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](CC([2H])([2H])[C@@]2(O)C#C)([H])[C@@]3([H])[C@](C4=CC([2H])=C(O)C([2H])=C4CC3)([H])CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (832.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 250 mg/mL (832.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 1 mg/mL (3.33 mM; ultrasonic and warming and heat to 80°C)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3286 mL 16.6428 mL 33.2856 mL
5 mM 0.6657 mL 3.3286 mL 6.6571 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO / DMSO 1 mM 3.3286 mL 16.6428 mL 33.2856 mL 83.2141 mL
DMSO / DMSO 5 mM 0.6657 mL 3.3286 mL 6.6571 mL 16.6428 mL
10 mM 0.3329 mL 1.6643 mL 3.3286 mL 8.3214 mL
15 mM 0.2219 mL 1.1095 mL 2.2190 mL 5.5476 mL
20 mM 0.1664 mL 0.8321 mL 1.6643 mL 4.1607 mL
25 mM 0.1331 mL 0.6657 mL 1.3314 mL 3.3286 mL
30 mM 0.1110 mL 0.5548 mL 1.1095 mL 2.7738 mL
40 mM 0.0832 mL 0.4161 mL 0.8321 mL 2.0804 mL
50 mM 0.0666 mL 0.3329 mL 0.6657 mL 1.6643 mL
60 mM 0.0555 mL 0.2774 mL 0.5548 mL 1.3869 mL
80 mM 0.0416 mL 0.2080 mL 0.4161 mL 1.0402 mL
100 mM 0.0333 mL 0.1664 mL 0.3329 mL 0.8321 mL
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Ethynyl Estradiol-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ethynyl Estradiol-d4350820-06-317α-Ethynylestradiol-d4Ethynylestradiol-d4Estrogen Receptor/ERREndogenous MetaboliteInhibitorinhibitorinhibit

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