2. Apoptosis
  3. Apoptosis
  4. Etidronic acid disodium

Etidronic acid disodium  (Synonyms: Etidronate disodium; HEDPA disodium; HEDP disodium)

Cat. No.: HY-B0302A Purity: ≥98.0%
SDS COA Handling Instructions

Molarity Calculator

Etidronic acid (Etidronate) disodium is an orally and intravenously active bisphosphonate. Etidronic acid disodium inhibits resorption of bone, reduces arterial calcification and can be used for osteoporosis research. Etidronic acid disodium has anticancer activity. Etidronic acid disodium is a chelating agent and can be used to remove heavy metal in water.

For research use only. We do not sell to patients.

Etidronic acid disodium Chemical Structure

Etidronic acid disodium Chemical Structure

CAS No. : 7414-83-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 28 In-stock
Solution
10 mM * 1 mL in Water USD 28 In-stock
Solid
100 mg USD 25 In-stock
500 mg USD 40 In-stock
1 g USD 60 In-stock
5 g   Get quote  
10 g   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Etidronic acid disodium:

Etidronic acid disodium Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Etidronic acid disodium

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Etidronic acid (Etidronate) disodium is an orally and intravenously active bisphosphonate. Etidronic acid disodium inhibits resorption of bone, reduces arterial calcification and can be used for osteoporosis research. Etidronic acid disodium has anticancer activity. Etidronic acid disodium is a chelating agent and can be used to remove heavy metal in water[1][2][3][4].

In Vitro

Etidronic acid (Etidronate) (10 mM, 24 h) disodium shows cytotoxicity, causes a decrease in the S-phase population and an increase in the G2/M population, induces p53 mutation in MCF-7 cells[3].
Etidronic acid (100 nM, 24 h) disodium induces osteoclast apoptosis, which displays characteristics of apoptosis, including chromatin condensation and changed cellular and nuclear morphology, detected by fluorescence microscopy[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Etidronic acid disodium Related Antibodies
Clinical Trial
Molecular Weight

249.99

Formula

C2H6Na2O7P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(P(O)(O[Na])=O)(P(O)(O[Na])=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (200.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0002 mL 20.0008 mL 40.0016 mL
5 mM 0.8000 mL 4.0002 mL 8.0003 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.0002 mL 20.0008 mL 40.0016 mL 100.0040 mL
5 mM 0.8000 mL 4.0002 mL 8.0003 mL 20.0008 mL
10 mM 0.4000 mL 2.0001 mL 4.0002 mL 10.0004 mL
15 mM 0.2667 mL 1.3334 mL 2.6668 mL 6.6669 mL
20 mM 0.2000 mL 1.0000 mL 2.0001 mL 5.0002 mL
25 mM 0.1600 mL 0.8000 mL 1.6001 mL 4.0002 mL
30 mM 0.1333 mL 0.6667 mL 1.3334 mL 3.3335 mL
40 mM 0.1000 mL 0.5000 mL 1.0000 mL 2.5001 mL
50 mM 0.0800 mL 0.4000 mL 0.8000 mL 2.0001 mL
60 mM 0.0667 mL 0.3333 mL 0.6667 mL 1.6667 mL
80 mM 0.0500 mL 0.2500 mL 0.5000 mL 1.2500 mL
100 mM 0.0400 mL 0.2000 mL 0.4000 mL 1.0000 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Etidronic acid disodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Etidronic acid disodium7414-83-7Etidronate disodiumHEDPA disodiumHEDP disodiumApoptosisInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Etidronic acid disodium
Cat. No.:
HY-B0302A
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.