2. Apoptosis
  3. Apoptosis
  4. Euphorbia Factor L2

Euphorbia factor L2, a lathyrane diterpenoid isolated from caper euphorbia seed (the seeds of Euphorbia lathyris L.), has been traditionally applied to treat cancer. Euphorbia factor L2 shows potent cytotoxicity and induces apoptosis via a mitochondrial pathway.

For research use only. We do not sell to patients.

Euphorbia Factor L2 Chemical Structure

Euphorbia Factor L2 Chemical Structure

CAS No. : 218916-51-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 276 In-stock
Solution
10 mM * 1 mL in DMSO USD 276 In-stock
Solid
1 mg USD 85 In-stock
5 mg USD 195 In-stock
10 mg USD 280 In-stock
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Based on 1 publication(s) in Google Scholar

Euphorbia Factor L2 Related Antibodies

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Description

Euphorbia factor L2, a lathyrane diterpenoid isolated from caper euphorbia seed (the seeds of Euphorbia lathyris L.), has been traditionally applied to treat cancer. Euphorbia factor L2 shows potent cytotoxicity and induces apoptosis via a mitochondrial pathway[1].

Molecular Weight

642.73

Formula

C38H42O9
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(/C(C)=C/[C@](C1(C)C)([H])[C@]1([H])C[C@H]2OC(C3=CC=CC=C3)=O)[C@](C[C@H](C)[C@@H]4OC(C5=CC=CC=C5)=O)(OC(C)=O)[C@@]4([H])[C@@H](OC(C)=O)C2=C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (129.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5559 mL 7.7793 mL 15.5586 mL
5 mM 0.3112 mL 1.5559 mL 3.1117 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 6.25 mg/mL (9.72 mM); Clear solution

    This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5559 mL 7.7793 mL 15.5586 mL 38.8966 mL
5 mM 0.3112 mL 1.5559 mL 3.1117 mL 7.7793 mL
10 mM 0.1556 mL 0.7779 mL 1.5559 mL 3.8897 mL
15 mM 0.1037 mL 0.5186 mL 1.0372 mL 2.5931 mL
20 mM 0.0778 mL 0.3890 mL 0.7779 mL 1.9448 mL
25 mM 0.0622 mL 0.3112 mL 0.6223 mL 1.5559 mL
30 mM 0.0519 mL 0.2593 mL 0.5186 mL 1.2966 mL
40 mM 0.0389 mL 0.1945 mL 0.3890 mL 0.9724 mL
50 mM 0.0311 mL 0.1556 mL 0.3112 mL 0.7779 mL
60 mM 0.0259 mL 0.1297 mL 0.2593 mL 0.6483 mL
80 mM 0.0194 mL 0.0972 mL 0.1945 mL 0.4862 mL
100 mM 0.0156 mL 0.0778 mL 0.1556 mL 0.3890 mL
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Euphorbia Factor L2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Euphorbia Factor L2218916-51-9Euphorbia Factor L 2Euphorbia Factor L-2ApoptosisInhibitorinhibitorinhibit

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