1. Epigenetics
  2. Histone Methyltransferase
  3. EZH2-IN-21

EZH2-IN-21 is a potent inhibitor of the histone lysine methyltransferase enhancer of zeste homologue 2 (EZH2) with anticancer activity. EZH2-IN-21 is competitive with the cofactor SAM and noncompetitive with peptide or nucleosome substrates.

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EZH2-IN-21 Chemical Structure

EZH2-IN-21 Chemical Structure

CAS No. : 923894-97-7

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Description

EZH2-IN-21 is a potent inhibitor of the histone lysine methyltransferase enhancer of zeste homologue 2 (EZH2) with anticancer activity. EZH2-IN-21 is competitive with the cofactor SAM and noncompetitive with peptide or nucleosome substrates[1].

Molecular Weight

379.46

Formula

C21H25N5O2

CAS No.
SMILES

O=C(C1=CC(C2CC2)=NC3=C1C=NN3C(C)C)NCC4=C(C)C=C(C)NC4=O

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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EZH2-IN-21
Cat. No.:
HY-113786
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