2. Stem Cell/Wnt
  3. Wnt
  4. F7H

F7H is a Frizzled receptor FZD7 antagonist (IC50: 1.25 μM). Frizzled receptors (FZDs) influence Wnt signaling, mediating embryonic development and tissue homeostasis. F7H is a potent ligand for the FZD7 transmembrane domain (TMD).

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F7H Chemical Structure

F7H Chemical Structure

CAS No. : 897109-93-2

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5 mg USD 130 In-stock
10 mg USD 200 In-stock
25 mg USD 340 In-stock
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Based on 1 publication(s) in Google Scholar

F7H Related Antibodies

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Description

F7H is a Frizzled receptor FZD7 antagonist (IC50: 1.25 μM). Frizzled receptors (FZDs) influence Wnt signaling, mediating embryonic development and tissue homeostasis. F7H is a potent ligand for the FZD7 transmembrane domain (TMD)[1].

IC50 & Target

IC50: 1.25 μM (Frizzled receptor, FZD7)[1]
Molecular Weight

463.55

Formula

C24H18FN3O2S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(C=C1)F)NC2=CC=C(C=C2)SCC(NC3=NC(C4=CC=CC=C4)=CS3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (269.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1573 mL 10.7863 mL 21.5726 mL
5 mM 0.4315 mL 2.1573 mL 4.3145 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1573 mL 10.7863 mL 21.5726 mL 53.9316 mL
5 mM 0.4315 mL 2.1573 mL 4.3145 mL 10.7863 mL
10 mM 0.2157 mL 1.0786 mL 2.1573 mL 5.3932 mL
15 mM 0.1438 mL 0.7191 mL 1.4382 mL 3.5954 mL
20 mM 0.1079 mL 0.5393 mL 1.0786 mL 2.6966 mL
25 mM 0.0863 mL 0.4315 mL 0.8629 mL 2.1573 mL
30 mM 0.0719 mL 0.3595 mL 0.7191 mL 1.7977 mL
40 mM 0.0539 mL 0.2697 mL 0.5393 mL 1.3483 mL
50 mM 0.0431 mL 0.2157 mL 0.4315 mL 1.0786 mL
60 mM 0.0360 mL 0.1798 mL 0.3595 mL 0.8989 mL
80 mM 0.0270 mL 0.1348 mL 0.2697 mL 0.6741 mL
100 mM 0.0216 mL 0.1079 mL 0.2157 mL 0.5393 mL
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F7H Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

F7H897109-93-2WntFrizzled receptorInhibitorinhibitorinhibit

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