(E)-Flavokawain A

Cat. No.: HY-N5106 Purity: 99.79%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

(E)-Flavokawain A, a chalcone extracted from Kava, has anticarcinogenic effect. (E)-Flavokawain A induces apoptosis in bladder cancer cells by involvement of bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice.

For research use only. We do not sell to patients.

(E)-Flavokawain A Chemical Structure

CAS No. : 37951-13-6

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
20 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (E)-Flavokawain A:

Flavokawain A Get quote
(E)-Flavokawain A (Standard) Get quote

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Biological Activity
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References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 20 μM Compound: 6	Inhibition of TNFalpha induced NF-kappaB activation in human A549 cells by luciferase reporter gene assay Inhibition of TNFalpha induced NF-kappaB activation in human A549 cells by luciferase reporter gene assay	[PMID: 19883086]
A549	IC₅₀	11.6 μg/mL Compound: Flavokawain A	Inhibition of TNF-alpha-induced NF-kappaB expressed in human A549 cells treated 1 hr after TNFalpha challenge measured after 6 hrs by luciferase reporter gene assay Inhibition of TNF-alpha-induced NF-kappaB expressed in human A549 cells treated 1 hr after TNFalpha challenge measured after 6 hrs by luciferase reporter gene assay	[PMID: 19716299]
DU-145	GI₅₀	30.8 μM Compound: 4	Cytotoxicity against human DU145 cells after 48 hrs Cytotoxicity against human DU145 cells after 48 hrs	[PMID: 18798609]
HCT-116	IC₅₀	10.6 μM Compound: 1c	Antiproliferative activity against human HCT116 cells after 48 hrs by SRB assay Antiproliferative activity against human HCT116 cells after 48 hrs by SRB assay	[PMID: 30041135]
HT-29	GI₅₀	45.3 μM Compound: 4	Cytotoxicity against human HT29 cells after 48 hrs Cytotoxicity against human HT29 cells after 48 hrs	[PMID: 18798609]
K562	GI₅₀	20.5 μM Compound: 4	Cytotoxicity against human K562 cells after 48 hrs Cytotoxicity against human K562 cells after 48 hrs	[PMID: 18798609]
M14	GI₅₀	22.5 μM Compound: 4	Cytotoxicity against human M14 cells after 48 hrs Cytotoxicity against human M14 cells after 48 hrs	[PMID: 18798609]
MCF7	GI₅₀	17.5 μM Compound: 4	Cytotoxicity against human MCF7 cells after 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs	[PMID: 18798609]
MDCK-II	IC₅₀	3 μM Compound: 24	Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by fluorimetry Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by fluorimetry	[PMID: 22112540]
NCI-H460	GI₅₀	24.1 μM Compound: 4	Cytotoxicity against human H460 cells after 48 hrs Cytotoxicity against human H460 cells after 48 hrs	[PMID: 18798609]
NIH3T3	IC₅₀	11 μM Compound: 2a	Inhibition of cobalt chloride-induced HIF-1 activation expressed in mouse NIH3T3 cells after 8 hrs by luciferase reporter gene assay Inhibition of cobalt chloride-induced HIF-1 activation expressed in mouse NIH3T3 cells after 8 hrs by luciferase reporter gene assay	[PMID: 21112783]
NIH3T3	GI₅₀	17.2 μM Compound: 4	Cytotoxicity against BALB mouse 3T3 cells after 48 hrs Cytotoxicity against BALB mouse 3T3 cells after 48 hrs	[PMID: 18798609]
PC-3	GI₅₀	15.2 μM Compound: 4	Cytotoxicity against human PC3 cells after 48 hrs Cytotoxicity against human PC3 cells after 48 hrs	[PMID: 18798609]
Vero	IC₅₀	> 25 μM Compound: 4	Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C4 in african green monkey Vero cells after 120 hrs Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C4 in african green monkey Vero cells after 120 hrs	[PMID: 18798609]

Molecular Weight

314.33

Formula

C₁₈H₁₈O₅

CAS No.

37951-13-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C(OC)C=C(OC)C=C1O)/C=C/C2=CC=C(OC)C=C2

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (79.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1814 mL	15.9069 mL	31.8137 mL
5 mM	0.6363 mL	3.1814 mL	6.3627 mL
10 mM	0.3181 mL	1.5907 mL	3.1814 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.79%

Select Batch:

Data Sheet (267 KB) SDS (252 KB)

COA (246 KB) HNMR (250 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Zi X, et al. Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice. Cancer Res. 2005 Apr 15;65(8):3479-86. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1814 mL	15.9069 mL	31.8137 mL	79.5343 mL
	5 mM	0.6363 mL	3.1814 mL	6.3627 mL	15.9069 mL
	10 mM	0.3181 mL	1.5907 mL	3.1814 mL	7.9534 mL
	15 mM	0.2121 mL	1.0605 mL	2.1209 mL	5.3023 mL
	20 mM	0.1591 mL	0.7953 mL	1.5907 mL	3.9767 mL
	25 mM	0.1273 mL	0.6363 mL	1.2725 mL	3.1814 mL
	30 mM	0.1060 mL	0.5302 mL	1.0605 mL	2.6511 mL
	40 mM	0.0795 mL	0.3977 mL	0.7953 mL	1.9884 mL
	50 mM	0.0636 mL	0.3181 mL	0.6363 mL	1.5907 mL
	60 mM	0.0530 mL	0.2651 mL	0.5302 mL	1.3256 mL

(E)-Flavokawain A Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-Flavokawain A37951-13-6ApoptosisInhibitorinhibitorinhibit

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(E)-Flavokawain A

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Complete Stock Solution Preparation Table

(E)-Flavokawain A Related Classifications

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