2. Apoptosis
  3. Apoptosis Bcl-2 Family
  4. Flurochloridone

Flurochloridone  (Synonyms: R-40244)

Cat. No.: HY-121337 Purity: 99.61%
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Flurochloridone (R-40244) is a selective preemergence and persistent herbicide. Flurochloridone induces endoplasmic reticulum (ER) stress and activated unfolded protein response (UPR) signaling pathways. Flurochloridone impairs cell viability and induces cytotoxicity and apoptosis mediated by ER stress via activating eIF2α-ATF4/ATF6-CHOP-Bim/Bax signaling pathways in TM4 cells.

For research use only. We do not sell to patients.

Flurochloridone Chemical Structure

Flurochloridone Chemical Structure

CAS No. : 61213-25-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Based on 1 publication(s) in Google Scholar

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Flurochloridone Related Antibodies

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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Description

Flurochloridone (R-40244) is a selective preemergence and persistent herbicide. Flurochloridone induces endoplasmic reticulum (ER) stress and activated unfolded protein response (UPR) signaling pathways. Flurochloridone impairs cell viability and induces cytotoxicity and apoptosis mediated by ER stress via activating eIF2α-ATF4/ATF6-CHOP-Bim/Bax signaling pathways in TM4 cells[1][2].

Molecular Weight

312.12

Formula

C12H10Cl2F3NO
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

O=C1N(CC(C1Cl)CCl)C2=CC=CC(C(F)(F)F)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (560.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2039 mL 16.0195 mL 32.0390 mL
5 mM 0.6408 mL 3.2039 mL 6.4078 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2039 mL 16.0195 mL 32.0390 mL 80.0974 mL
5 mM 0.6408 mL 3.2039 mL 6.4078 mL 16.0195 mL
10 mM 0.3204 mL 1.6019 mL 3.2039 mL 8.0097 mL
15 mM 0.2136 mL 1.0680 mL 2.1359 mL 5.3398 mL
20 mM 0.1602 mL 0.8010 mL 1.6019 mL 4.0049 mL
25 mM 0.1282 mL 0.6408 mL 1.2816 mL 3.2039 mL
30 mM 0.1068 mL 0.5340 mL 1.0680 mL 2.6699 mL
40 mM 0.0801 mL 0.4005 mL 0.8010 mL 2.0024 mL
50 mM 0.0641 mL 0.3204 mL 0.6408 mL 1.6019 mL
60 mM 0.0534 mL 0.2670 mL 0.5340 mL 1.3350 mL
80 mM 0.0400 mL 0.2002 mL 0.4005 mL 1.0012 mL
100 mM 0.0320 mL 0.1602 mL 0.3204 mL 0.8010 mL
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Flurochloridone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flurochloridone61213-25-0R-40244R40244R 40244ApoptosisBcl-2 FamilyherbicideapoptosisInhibitorinhibitorinhibit

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