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  4. FMS586 free base

FMS586 free base is a selective neuropeptide Y Y5 receptor antagonist with oral activity. FMS586 can completely block the significant increase in adrenocorticotropic hormone (ACTH) and cortisol caused by the Y(5) selective agonist hPP. FMS586 also reversed the significant upregulation of adrenocorticotropic hormone (CRF) and antidiuretic hormone (AVP) mRNA expression induced by central injection of hPP. FMS586 provides the first evidence that selective stimulation of Y(5) receptors triggers activation of the HPA axis.

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FMS586 free base Chemical Structure

FMS586 free base Chemical Structure

CAS No. : 302556-51-0

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Description

FMS586 free base is a selective neuropeptide Y Y5 receptor antagonist with oral activity. FMS586 can completely block the significant increase in adrenocorticotropic hormone (ACTH) and cortisol caused by the Y(5) selective agonist hPP. FMS586 also reversed the significant upregulation of adrenocorticotropic hormone (CRF) and antidiuretic hormone (AVP) mRNA expression induced by central injection of hPP. FMS586 provides the first evidence that selective stimulation of Y(5) receptors triggers activation of the HPA axis[1].

Molecular Weight

390.52

Formula

C24H30N4O
CAS No.
SMILES

O=C(N(CCC1=CC=NC=C1)C)NC2=CC3=C(N(C4=C3CCCC4)C(C)C)C=C2
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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FMS586 free base Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

FMS586302556-51-0FMS 586FMS-586OthersInhibitorinhibitorinhibit

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