2. Metabolic Enzyme/Protease
  3. Aldehyde Dehydrogenase (ALDH)
  4. FSI-TN42

ALDH1A1/2-IN-1 is an ALDH1A1 and ALDH1A2 inhibitor that can be used for preventing spermatogenesis.

For research use only. We do not sell to patients.

FSI-TN42 Chemical Structure

FSI-TN42 Chemical Structure

CAS No. : 2445840-25-3

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FSI-TN42 Related Antibodies

Top Publications Citing Use of Products

View All Aldehyde Dehydrogenase (ALDH) Isoform Specific Products:

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ALDH1 ALDH2 ALDH3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ALDH1A1/2-IN-1 is an ALDH1A1 and ALDH1A2 inhibitor that can be used for preventing spermatogenesis[1].

Molecular Weight

492.44

Formula

C24H31Cl2N5O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCN(CC1)C2=CC=C(C(N3CCCCCC3)=C2)NC(C(Cl)Cl)=O)C4=CC=CN4C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (406.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0307 mL 10.1535 mL 20.3070 mL
5 mM 0.4061 mL 2.0307 mL 4.0614 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: 5 mg/mL (10.15 mM); Clear solution; Need ultrasonic

    This protocol yields a clear solution of 5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0307 mL 10.1535 mL 20.3070 mL 50.7676 mL
5 mM 0.4061 mL 2.0307 mL 4.0614 mL 10.1535 mL
10 mM 0.2031 mL 1.0154 mL 2.0307 mL 5.0768 mL
15 mM 0.1354 mL 0.6769 mL 1.3538 mL 3.3845 mL
20 mM 0.1015 mL 0.5077 mL 1.0154 mL 2.5384 mL
25 mM 0.0812 mL 0.4061 mL 0.8123 mL 2.0307 mL
30 mM 0.0677 mL 0.3385 mL 0.6769 mL 1.6923 mL
40 mM 0.0508 mL 0.2538 mL 0.5077 mL 1.2692 mL
50 mM 0.0406 mL 0.2031 mL 0.4061 mL 1.0154 mL
60 mM 0.0338 mL 0.1692 mL 0.3385 mL 0.8461 mL
80 mM 0.0254 mL 0.1269 mL 0.2538 mL 0.6346 mL
100 mM 0.0203 mL 0.1015 mL 0.2031 mL 0.5077 mL
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FSI-TN42 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FSI-TN422445840-25-3N42N 42N-42Aldehyde Dehydrogenase (ALDH)spermatogenesisInhibitorinhibitorinhibit

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