Fumaric acid-d₂

Name: Fumaric acid-d 2
Brand: MedChemExpress
SKU: HY-W015883S3
Rating: 4.5 (1 reviews)

Cat. No.: HY-W015883S3 Purity: 99.00%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Fumaric acid-d₂ is the deuterium labeled Fumaric acid[1]. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite[2].

For research use only. We do not sell to patients.

Fumaric acid-d<sub>2</sub> Chemical Structure

Fumaric acid-d₂ Chemical Structure

CAS No. : 24461-32-3

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Fumaric acid-d₂:

Fumaric acid In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Fumaric acid-d₂ is the deuterium labeled Fumaric acid[1]. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

118.08

Formula

C₄H₂D₂O₄

CAS No.

24461-32-3

Appearance

Solid

Color

White to off-white

SMILES

OC(/C([2H])=C([2H])/C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (211.72 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	8.4688 mL	42.3442 mL	84.6883 mL
5 mM	1.6938 mL	8.4688 mL	16.9377 mL
10 mM	0.8469 mL	4.2344 mL	8.4688 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.00%

Select Batch:

Data Sheet (270 KB) SDS (597 KB)

COA (246 KB) HNMR (542 KB) RP-HPLC (703 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Whelan DT, et al. Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairment. Clin Chim Acta. 1983 Aug 31;132(3):301-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	8.4688 mL	42.3442 mL	84.6883 mL	211.7209 mL
	5 mM	1.6938 mL	8.4688 mL	16.9377 mL	42.3442 mL
	10 mM	0.8469 mL	4.2344 mL	8.4688 mL	21.1721 mL
	15 mM	0.5646 mL	2.8229 mL	5.6459 mL	14.1147 mL
	20 mM	0.4234 mL	2.1172 mL	4.2344 mL	10.5860 mL
	25 mM	0.3388 mL	1.6938 mL	3.3875 mL	8.4688 mL
	30 mM	0.2823 mL	1.4115 mL	2.8229 mL	7.0574 mL
	40 mM	0.2117 mL	1.0586 mL	2.1172 mL	5.2930 mL
	50 mM	0.1694 mL	0.8469 mL	1.6938 mL	4.2344 mL
	60 mM	0.1411 mL	0.7057 mL	1.4115 mL	3.5287 mL
	80 mM	0.1059 mL	0.5293 mL	1.0586 mL	2.6465 mL
	100 mM	0.0847 mL	0.4234 mL	0.8469 mL	2.1172 mL