GAK inhibitor 2

Cat. No.: HY-147761: FAQs
Data Sheet Handling Instructions

Molarity Calculator

GAK inhibitor 2 (Compound 14g) is a potent cyclin G-associated kinase (GAK) inhibitor with an IC₅₀ of 0.024 μM. GAK inhibitor 2 shows antiviral activity with an EC₅₀ of 1.049 μM against dengue virus (DENV).

For research use only. We do not sell to patients.

GAK inhibitor 2 Chemical Structure

CAS No. : 2396706-31-1

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Antibiotic Isoform Specific Products:

View All Isoforms

Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC₅₀: 0.024 μM (GAK)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	> 10 μM Compound: 14g	Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by alamar blue reagent based cell viability assay Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by alamar blue reagent based cell viability assay	[PMID: 31757682]
Huh-7	EC₅₀	1.049 μM Compound: 14g	Antiviral activity against Dengue virus 2 infected in human HuH7 cells incubated for 48 hrs by luciferase reporter gene assay Antiviral activity against Dengue virus 2 infected in human HuH7 cells incubated for 48 hrs by luciferase reporter gene assay	[PMID: 31757682]

Molecular Weight

385.48

Formula

C₂₀H₂₃N₃O₃S

CAS No.

2396706-31-1

SMILES

COC1=CC=C(C2=NC3=C(N4C[C@@H](C)O[C@@H](C)C4)SN=C3C=C2)C=C1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Martinez-Gualda B, et al. Structure-activity relationship study of the pyridine moiety of isothiazolo[4,3-b]pyridines as antiviral agents targeting cyclin G-associated kinase. Bioorg Med Chem. 2020 Jan 1;28(1):115188. [Content Brief]

GAK inhibitor 2 Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GAK inhibitor 22396706-31-1GAK inhibitor2GAK inhibitor-2Dengue virusFlavivirusAntibioticDENVantiviraldengue virusInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks