Galanthamine-d₆

Name: Galanthamine-d 6
Brand: MedChemExpress
SKU: HY-76299S
Rating: 5.0 (1 reviews)

Cat. No.: HY-76299S Purity: 99.54%: FAQs
Data Sheet SDS COA Handling Instructions

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Galanthamine-d₆ (Galantamine-d6) is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM[1][2].

For research use only. We do not sell to patients.

Galanthamine-d<sub>6</sub> Chemical Structure

Galanthamine-d₆ Chemical Structure

CAS No. : 1128109-00-1

Size	Price	Stock	Quantity
1 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 810	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1300	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Galanthamine-d₆:

Galanthamine In-stock
Galanthamine-d₃ hydrochloride Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Galanthamine-d₆ (Galantamine-d6) is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

293.39

Formula

C₁₇H₁₅D₆NO₃

CAS No.

1128109-00-1

Unlabeled CAS

357-70-0

Appearance

Solid

Color

White to yellow

SMILES

O(C([2H])([2H])[2H])C1=C2C=3[C@]4([C@@](O2)(C[C@@H](O)C=C4)[H])CCN(C([2H])([2H])[2H])CC3C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (340.84 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4084 mL	17.0422 mL	34.0843 mL
5 mM	0.6817 mL	3.4084 mL	6.8169 mL
10 mM	0.3408 mL	1.7042 mL	3.4084 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.54%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (256 KB) HNMR (282 KB) RP-HPLC (262 KB) LCMS (151 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Melanie-Jayne R. Howes, et al. Acetylcholinesterase inhibitors of natural origin. International Journal of Research in Pharmaceutical and Biomedical Sciences 3(SI 1):67-86.

[3]. Kuryatov A, et al. Roles of accessory subunits in alpha4beta2(*) nicotinic receptors. Mol Pharmacol. 2008 Jul;74(1):132-43. [Content Brief]

[4]. Kita Y, et al. Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice. Psychopharmacology (Berl). 2013 Feb;225(3):543-51. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4084 mL	17.0422 mL	34.0843 mL	85.2108 mL
	5 mM	0.6817 mL	3.4084 mL	6.8169 mL	17.0422 mL
	10 mM	0.3408 mL	1.7042 mL	3.4084 mL	8.5211 mL
	15 mM	0.2272 mL	1.1361 mL	2.2723 mL	5.6807 mL
	20 mM	0.1704 mL	0.8521 mL	1.7042 mL	4.2605 mL
	25 mM	0.1363 mL	0.6817 mL	1.3634 mL	3.4084 mL
	30 mM	0.1136 mL	0.5681 mL	1.1361 mL	2.8404 mL
	40 mM	0.0852 mL	0.4261 mL	0.8521 mL	2.1303 mL
	50 mM	0.0682 mL	0.3408 mL	0.6817 mL	1.7042 mL
	60 mM	0.0568 mL	0.2840 mL	0.5681 mL	1.4202 mL
	80 mM	0.0426 mL	0.2130 mL	0.4261 mL	1.0651 mL
	100 mM	0.0341 mL	0.1704 mL	0.3408 mL	0.8521 mL