GBR 12783 dihydrochloride

Name: GBR 12783 dihydrochloride
Brand: MedChemExpress
SKU: HY-100968
Rating: 4.5 (1 reviews)

Cat. No.: HY-100968 Purity: 99.14%: FAQs
Data Sheet SDS COA Handling Instructions

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GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [³H]dopamine uptake by rat and mice striatal synaptosomes with IC₅₀s of 1.8 nM and 1.2 nM, respectively. GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.

For research use only. We do not sell to patients.

GBR 12783 dihydrochloride Chemical Structure

CAS No. : 67469-75-4

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of GBR 12783 dihydrochloride:

GBR 12783 Get quote

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Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vivo

GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (180-200 g)^[1]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; for 100 minutes
Result:	For a moderate electric shock intensity (0.4 mA), improveed retention performance, increased hippocampal acetylcholine release in vivo.

Molecular Weight

485.49

Formula

C₂₈H₃₄Cl₂N₂O

CAS No.

67469-75-4

Appearance

Solid

Color

White to off-white

SMILES

N1(CCOC(C2=CC=CC=C2)C3=CC=CC=C3)CCN(C/C=C/C4=CC=CC=C4)CC1.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 41.67 mg/mL (85.83 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0598 mL	10.2989 mL	20.5977 mL
5 mM	0.4120 mL	2.0598 mL	4.1195 mL
10 mM	0.2060 mL	1.0299 mL	2.0598 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.14%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (247 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Nail-Boucherie K, et al. The specific dopamine uptake inhibitor GBR 12783 improves learning of inhibitory avoidance and increases hippocampal acetylcholine release. Brain Res Cogn Brain Res. 1998 Oct;7(2):203-5. [Content Brief]

[2]. Bonnet JJ, et al. GBR 12783, a potent and selective inhibitor of dopamine uptake: biochemical studies in vivo and ex vivo. Eur J Pharmacol. 1986 Feb 18;121(2):199-209. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0598 mL	10.2989 mL	20.5977 mL	51.4944 mL
	5 mM	0.4120 mL	2.0598 mL	4.1195 mL	10.2989 mL
	10 mM	0.2060 mL	1.0299 mL	2.0598 mL	5.1494 mL
	15 mM	0.1373 mL	0.6866 mL	1.3732 mL	3.4330 mL
	20 mM	0.1030 mL	0.5149 mL	1.0299 mL	2.5747 mL
	25 mM	0.0824 mL	0.4120 mL	0.8239 mL	2.0598 mL
	30 mM	0.0687 mL	0.3433 mL	0.6866 mL	1.7165 mL
	40 mM	0.0515 mL	0.2575 mL	0.5149 mL	1.2874 mL
	50 mM	0.0412 mL	0.2060 mL	0.4120 mL	1.0299 mL
	60 mM	0.0343 mL	0.1716 mL	0.3433 mL	0.8582 mL
	80 mM	0.0257 mL	0.1287 mL	0.2575 mL	0.6437 mL