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  4. Gelatins

Gelatins is a non-toxic, non carcinogenic, biodegradable, and non irritating natural polymer derived from partial hydrolysis of collagen. Due to its strong liquid absorption and swelling ability, Gelatins has excellent hemostatic properties and can be used as a matrix material for the reduction, growth, and stability of metal nanoparticles. Gelatins can also be used for tumor cell culture and tumor therapy[1][2][3].

For research use only. We do not sell to patients.

Gelatins Chemical Structure

Gelatins Chemical Structure

CAS No. : 9000-70-8

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Gelatins Related Antibodies

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Description

Gelatins is a non-toxic, non carcinogenic, biodegradable, and non irritating natural polymer derived from partial hydrolysis of collagen. Due to its strong liquid absorption and swelling ability, Gelatins has excellent hemostatic properties and can be used as a matrix material for the reduction, growth, and stability of metal nanoparticles. Gelatins can also be used for tumor cell culture and tumor therapy[1][2][3].
In Vitro

Gelatins (6-12 %, 5 days) forms gelatin@NWF Derivatives serve as long-term storage scaffolds to promote the formation of prostate tumor cell spheroids for culturing tumor cells[3].
Gelatins (0-200 μg/mL, 24 h) can enhance cell adhesion, growth, and wound healing of HaCaT cells, and protect HaCaT cells from H2O2 induced cell damage[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gelatins Related Antibodies

Cell Viability Assay[3].

Cell Line: Human prostate cancer cell DU145
Concentration: 6-12 %
Incubation Time: 5 days
Result: Supported more cell growth than pure non-woven fabric (NWF) scaffolds

Cell Viability Assay[5].

Cell Line: Human keratinocyte-derived (HaCaT) cells
Concentration: 0-200 μg/mL
Incubation Time: 24 h
Result: Increased cell growth percentage in the concentration range of 25-75 μg/mL, but decreased cell growth percentage in the concentration range of 100-200 μg/mL.
In Vivo

Gelatins (20 μg/kg; i.p.) has a good improvement effect on exercise recovery of spinal cord injury in Wistar rats by forming Au NPs/Gelatin nanocomposite[1].
Gelatins has excellent hemostatic effects on rat femoral artery injury after crosslinking with biocompatible dialdehyde starch (DAS) to synthesize aminated gelatin sponge[2].
Gelatins (10 mg/kg; once every two days; 14 days; i.v.) is modified with PEG to form a pH/enzyme responsive complex, which specifically delivers doxorubicin (DOX) (HY-15142A) and exhibits anti-tumor activity in S180 ectopic tumor mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Traumatic spinal cord injury Wistar rat model[1].
Dosage: 20 μg/kg Au NPs/Gelatin nanocomposite
Administration: Intraperitoneal injection (i.p.)
Result: Improved hind limb function, reduced cavity area, increased the number of ventral motor neurons, and demonstrated higher BBB scores and lower delayed responses in sensory tests.
Animal Model: SD female rat femoral injury model[2].
Dosage: A pre-weighed hemostatic sponge
Administration: Apply to the wound
Result: Reduced hemostasis time and blood loss.
Animal Model: Female ICR mouse model of ectopic transplantation of mouse sarcoma cell line S180[4].
Dosage: 10 mg DOX/kg
Administration: Intravenous injection (i.v.); once every two days; 14 days
Result: Reduced tumor volume, prevented tumor cell spread, and lowered cardiac toxicity.
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

[Gelatins]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (Need ultrasonic)

DMSO : 4.55 mg/mL (ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 10 mg/mL; Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (247 KB)

Handling Instructions (2659 KB)
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Gelatins Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gelatins9000-70-8Biochemical Assay Reagentshemostasismatrix materialnanocompositestumor cell cultureInhibitorinhibitorinhibit

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