2. Gene
  3. IL18BP - interleukin 18 binding protein Gene

IL18BP - interleukin 18 binding protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FVH; IL18BPa

Gene ID: 10068 | Gene type: protein coding

About IL18BP

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:71,998,909-72,008,200 (from NCBI)

This gene has 18 transcripts (splice variants), 89 orthologues and is associated with 1 phenotype. Broad expression in spleen (RPKM 11.4), appendix (RPKM 6.6) and 24 other tissues.

Summary

The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

IL18BP Products(7)

mRNA Protein Name
NM_001039659.2 NP_001034748.1 interleukin-18-binding protein isoform a precursor
NM_001039660.2 NP_001034749.1 interleukin-18-binding protein isoform a precursor
NM_001145055.1 NP_001138527.1 interleukin-18-binding protein isoform b precursor
NM_001145057.1 NP_001138529.1 interleukin-18-binding protein isoform a precursor
NM_005699.3 NP_005690.2 interleukin-18-binding protein isoform c precursor
NM_173042.2 NP_766630.2 interleukin-18-binding protein isoform a precursor
NM_173044.3 NP_766632.2 interleukin-18-binding protein isoform d precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables interleukin-18 binding IDA
IDA: Inferred from direct assay
10023777 GOA
Biological Process GO Annotation Evidence Reference Source
involved in T-helper 1 type immune response IDA
IDA: Inferred from direct assay
10023777 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-18-binding protein

MC51L-53L-54L homolog gene product

Recombinant IL18BP Proteins

Cat. No. Product Name Accession Purity
HY-P7211 IL-18BP Protein, Human (CHO) O95998-2 (T31-G194) ≥95%
HY-P72575 IL-18BP Protein, Human (HEK293, hFc) AAD17187.1 (T29-G192) ≥95%
HY-P77709 IL-18BP Protein, Human (HEK293, His) O95998-2 (T31-G194) ≥95%
HY-P78156 IL-18BP Protein, Human (Biotinylated, HEK293, His-Avi) O95998-2 (T31-G194) ≥95%

Related Diseases

Diseases Alias
Hepatitis, Fulminant Viral

Hepatitis, Fulminant Viral, Susceptibility To

FVH

Fulminant Viral Hepatitis

{Hepatitis, Fulminant Viral, Susceptibility To}
Molluscum Contagiosum

Water Warts

Molluscum Verrucosum
Cowpox

Yaba
Viral Hepatitis

Animal Viral Hepatitis

Hepatitis, Viral, Animal

Human Viral Hepatitis

Viral Hepatitis With Hepatic Coma
Crohn'S Disease

Crohn Disease

Pediatric Crohn'S Disease

Regional Enteritis

Crohn'S Disease Of Large Bowel

Granulomatous Colitis

Enteritis, Granulomatous

Enteritis

Crohn'S Disease Of Colon

Colitis, Granulomatous

Crohn'S Enteritis

Enteritis, Regional

Ileitis

Adenoviral Enteritis

Acute Gastroenteropathy Due To Norwalk Agent

Viral Gastroenteritis Due To Norwalk Agent

Winter Vomiting

Epidemic Winter Vomiting Disease

Small Round Structured Virus Enteritis

Epidemic Vomiting Syndrome

Epidemic Vomiting

Epidemic Nausea

Epidemic Viral Gastroenteritis Due To Norwalk Virus

Noroviral Enteritis

Crohn Disease Nos

Crohns

Cd - [Crohn'S Disease]

Regional Enteritis Of Bowel

Crohn'S Regional Enteritis

Cobble-Stone Appearance Of Intestine

Intestinal Ulcer And Erosion Due To Crohn Disease

Granulomatous Enteritis
Adult-Onset Still'S Disease

Adult-Onset Still Disease

Adult Onset Still'S Disease

Adult Still'S Disease

Still'S Disease Adult Onset

Aosd

Wissler-Fanconi Syndrome

Stills Disease Adult-Onset

Still'S Disease, Adult-Onset

Wissler'S Syndrome
Smallpox

Variola

Ordinary Smallpox

Alastrim

Amaas
Toxic Optic Neuropathy
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Hemophagocytic Lymphohistiocytosis

Lymphohistiocytosis, Hemophagocytic

Haemophagocytic Syndrome

Lymphohistiocytosis Hemophagocytic

Hemophagocytic Syndrome

Familial Hemophagocytic Lymphocytosis

Histiocytoses Of Mononuclear Phagocytes

Haemophagocytic Lymphohistiocytosis Nos
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-102019 NSC61610 Inhibitor 99.50% Unkown
HY-160793 NSC80734 Inhibitor 98.08% Unkown
HY-RS06709 IL18BP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus IL18BP MGD MGI:1333800
Canis familiaris IL18BP VGNC VGNC:41952
Rattus norvegicus IL18BP RGD RGD:620042
Macaca mulatta IL18BP VGNC VGNC:73713
Bos taurus IL18BP VGNC VGNC:54438
Felis catus IL18BP VGNC VGNC:82043
Others IL18BP NCBI