IL18BP - interleukin 18 binding protein Gene

Homo sapiens

Also known as FVH; IL18BPa

Gene ID: 10068 | Gene type: protein coding

About IL18BP

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:71,998,909-72,008,200 (from NCBI)

This gene has 18 transcripts (splice variants), 89 orthologues and is associated with 1 phenotype. Broad expression in spleen (RPKM 11.4), appendix (RPKM 6.6) and 24 other tissues.

Summary

The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

IL18BP Products(7)

mRNA	Protein	Name
NM_001039659.2	NP_001034748.1	interleukin-18-binding protein isoform a precursor
NM_001039660.2	NP_001034749.1	interleukin-18-binding protein isoform a precursor
NM_001145055.1	NP_001138527.1	interleukin-18-binding protein isoform b precursor
NM_001145057.1	NP_001138529.1	interleukin-18-binding protein isoform a precursor
NM_005699.3	NP_005690.2	interleukin-18-binding protein isoform c precursor
NM_173042.2	NP_766630.2	interleukin-18-binding protein isoform a precursor
NM_173044.3	NP_766632.2	interleukin-18-binding protein isoform d precursor

Protein Preferred Names

Protein Names

interleukin-18-binding protein

MC51L-53L-54L homolog gene product

Recombinant IL18BP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7211	IL-18BP Protein, Human (CHO)	O95998-2 (T31-G194)	≥95%
HY-P72575	IL-18BP Protein, Human (HEK293, hFc)	AAD17187.1 (T29-G192)	≥95%
HY-P77709	IL-18BP Protein, Human (HEK293, His)	O95998-2 (T31-G194)	≥95%
HY-P78156	IL-18BP Protein, Human (Biotinylated, HEK293, His-Avi)	O95998-2 (T31-G194)	≥95%

Related Diseases

Diseases

Alias

Hepatitis, Fulminant Viral

Hepatitis, Fulminant Viral, Susceptibility To	FVH
Fulminant Viral Hepatitis	{Hepatitis, Fulminant Viral, Susceptibility To}

Molluscum Contagiosum

Water Warts

Molluscum Verrucosum

Cowpox

Yaba

Viral Hepatitis

Animal Viral Hepatitis	Hepatitis, Viral, Animal
Human Viral Hepatitis	Viral Hepatitis With Hepatic Coma

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Adult-Onset Still'S Disease

Adult-Onset Still Disease	Adult Onset Still'S Disease
Adult Still'S Disease	Still'S Disease Adult Onset
Aosd	Wissler-Fanconi Syndrome
Stills Disease Adult-Onset	Still'S Disease, Adult-Onset
Wissler'S Syndrome

Smallpox

Variola	Ordinary Smallpox
Alastrim	Amaas

Toxic Optic Neuropathy

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Hemophagocytic Lymphohistiocytosis

Lymphohistiocytosis, Hemophagocytic	Haemophagocytic Syndrome
Lymphohistiocytosis Hemophagocytic	Hemophagocytic Syndrome
Familial Hemophagocytic Lymphocytosis	Histiocytoses Of Mononuclear Phagocytes
Haemophagocytic Lymphohistiocytosis Nos

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-102019	NSC61610	Inhibitor	99.50%	Unkown
HY-160793	NSC80734	Inhibitor	98.08%	Unkown
HY-RS06709	IL18BP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IL18BP	MGD	MGI:1333800
Canis familiaris	IL18BP	VGNC	VGNC:41952
Rattus norvegicus	IL18BP	RGD	RGD:620042
Macaca mulatta	IL18BP	VGNC	VGNC:73713
Bos taurus	IL18BP	VGNC	VGNC:54438
Felis catus	IL18BP	VGNC	VGNC:82043
Others	IL18BP	NCBI

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