DPP3 - dipeptidyl peptidase 3 Gene

Homo sapiens

Also known as DPPIII

Gene ID: 10072 | Gene type: protein coding

About DPP3

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,480,434-66,509,657 (from NCBI)

This gene has 16 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in colon (RPKM 13.2), appendix (RPKM 10.5) and 25 other tissues.

Summary

This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl Aminopeptidase activity, cleaving Xaa-Pro Dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]

DPP3 Products(3)

mRNA	Protein	Name
NM_001256670.2	NP_001243599.1	dipeptidyl peptidase 3 isoform 2
NM_005700.5	NP_005691.2	dipeptidyl peptidase 3 isoform 1
NM_130443.4	NP_569710.2	dipeptidyl peptidase 3 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables dipeptidyl-peptidase activity	IDA IDA: Inferred from direct assay	9425109	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19615732	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	9425109	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in proteolysis	IDA IDA: Inferred from direct assay	9425109	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPP3 Protein Structure

Peptidase_M49

0
200
400
600
737 a.a.

Protein Preferred Names

Protein Names

dipeptidyl peptidase 3

DPP III

Recombinant DPP3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70112	Dipeptidyl peptidase 3/DPP3 Protein, Human (His)	Q9NY33 (M1-A737)	≥95%

Related Diseases

Diseases

Alias

Cardiac Arrest

Cardiopulmonary Arrest	Circulatory Arrest
Heart Arrest

Myasthenic Syndrome, Congenital, 10

Congenital Myasthenic Syndrome 10	CMS10
Lgm	Myasthenia, Limb-Girdle, Familial
Myasthenia, Limb-Girdle, Familial, Formerly	Lgm, Formerly
Congenital Myasthenic Syndrome Type Ib, Formerly	Cms1b, Formerly
Cms Ib, Formerly	Myasthenic Myopathy, Formerly
Familial Limb-Girdle Myasthenia	Cms1b
Cms Ib	Congenital Myasthenic Syndrome Type 1b
Congenital Myasthenic Syndrome Type Ib	Myasthenic Myopathy
Myasthenic Syndrome, Congenital, Type 10	Congenital Myasthenic Syndrome Ib
Myopathy In Myasthenia Gravis

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03962	DPP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W127832	Ru(dpp)3(PF6)2		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DPP3	VGNC	VGNC:61603
Rattus norvegicus	DPP3	RGD	RGD:621127
Mus musculus	DPP3	MGD	MGI:1922471
Canis familiaris	DPP3	VGNC	VGNC:40073
Bos taurus	DPP3	VGNC	VGNC:28187
Others	DPP3	NCBI

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