GPC6 - glypican 6 Gene

Homo sapiens

Also known as OMIMD1

Gene ID: 10082 | Gene type: protein coding

About GPC6

Cytogenetic location: 13q31.3-q32.1 Genomic coordinates (GRCh38): 13:93,216,529-94,408,020 (from NCBI)

This gene has 2 transcripts (splice variants), 282 orthologues, 5 paralogues and is associated with 3 phenotypes. Broad expression in gall bladder (RPKM 6.5), urinary bladder (RPKM 3.9) and 21 other tissues.

Summary

The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Mutations in this gene are associated with omodysplasia 1. [provided by RefSeq, Nov 2016]

GPC6 Products(1)

mRNA	Protein	Name
NM_005708.5	NP_005699.1	glypican-6 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration	IDA IDA: Inferred from direct assay	21871017	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPC6 Protein Structure

Glypican

0
100
200
300
400
500
555 a.a.

Protein Preferred Names

Protein Names

glypican-6

glypican proteoglycan 6

GPC6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GPC6	Q9Y625	GPC4	Homo sapiens	O75487	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Omodysplasia 1

OMOD1	Autosomal Recessive Omodysplasia
Omodysplasia Autosomal Recessive	Omodysplasia Generalized Form
Omodysplasia Type 1	Omodysplasia, Generalized Form
Omodysplasia, Autosomal Recessive	Micromelic Dysplasia, Congenital, With Dislocation Of Radius
Micromelic Dysplasia Congenita With Dislocation Of Radius	Micromelic Dysplasia-Dislocation Of Radius Syndrome
Micromelic Dysplasia Congenital With Dislocation Of Radius	Omodysplasia, Type 1

Omodysplasia

Omodysplasia Type 1

Omodysplasia 2

Keipert Syndrome

Nasodigitoacoustic Syndrome	KPTS
Nasodigitoacoustic Syndrome, Formerly

Simpson-Golabi-Behmel Syndrome, Type 1

Simpson-Golabi-Behmel Syndrome Type 1	Simpson-Golabi-Behmel Syndrome
SGBS1	Golabi-Rosen Syndrome
Simpson Dysmorphia Syndrome	Sgbs
Bulldog Syndrome	Dgsx
Sdys	Dysplasia Gigantism Syndrome, X-Linked
X-Linked Dysplasia Gigantism Syndrome	Dgsx Golabi-Rosen Syndrome
Sara Angers Syndrome	Sgb Syndrome
Mental Retardation-Overgrowth Syndrome	Simpson Dysplasia Syndrome
Simpson Syndrome	Simpson-Golabi-Behmel Syndrome 1
Dysplasia Gigantism Syndrome X-Linked

Hereditary Multiple Exostoses

Multiple Congenital Exostosis	Hereditary Multiple Exostoses 1
Hereditary Multiple Exostoses 2	Hereditary Multiple Exostoses 3
Multiple Exostosis Syndromes	Multiple Ostechondromas
Osteochondromatosis Syndrome	Exostoses Multiple Hereditary
Exostoses, Multiple Hereditary

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Body Dysmorphic Disorder

Dysmorphophobia	Body Dysmorphia
Dysmorphic Syndrome	Body Dysmorphic Disorders

Osteochondrodysplasia

Skeletal Dysplasia	Chondrodystrophy
Congenital Anomaly Of Cartilage	Osteochondrodysplasias
Cartilage Development Disorder	Osteochondrodysplasia Syndrome
Dysplasia, Skeletal	Mucopolysaccharidosis Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05631	GPC6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GPC6	VGNC	VGNC:106263
Rattus norvegicus	GPC6	RGD	RGD:1593308
Mus musculus	GPC6	MGD	MGI:1346322
Felis catus	GPC6	VGNC	VGNC:102215

Name
Email *

	Sorry, but the email address you supplied was invalid.