GPC4 - glypican 4 Gene

Homo sapiens

Also known as KPTS; K-glypican

Gene ID: 2239 | Gene type: protein coding

About GPC4

Cytogenetic location: Xq26.2 Genomic coordinates (GRCh38): X:133,300,103-133,415,489 (from NCBI)

This gene has 1 transcript (splice variant), 203 orthologues, 5 paralogues and is associated with 6 phenotypes. Broad expression in placenta (RPKM 22.5), kidney (RPKM 16.2) and 22 other tissues.

Summary

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008]

GPC4 Products(1)

mRNA	Protein	Name
NM_001448.3	NP_001439.2	glypican-4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	29276006	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	10585884	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPC4 Protein Structure

Glypican

0
100
200
300
400
500
556 a.a.

Protein Preferred Names

Protein Names

glypican-4

dJ900E8.1 (glypican 4)

Related Diseases

Diseases

Alias

Keipert Syndrome

Nasodigitoacoustic Syndrome	KPTS
Nasodigitoacoustic Syndrome, Formerly

Simpson-Golabi-Behmel Syndrome, Type 1

Simpson-Golabi-Behmel Syndrome Type 1	Simpson-Golabi-Behmel Syndrome
SGBS1	Golabi-Rosen Syndrome
Simpson Dysmorphia Syndrome	Sgbs
Bulldog Syndrome	Dgsx
Sdys	Dysplasia Gigantism Syndrome, X-Linked
X-Linked Dysplasia Gigantism Syndrome	Dgsx Golabi-Rosen Syndrome
Sara Angers Syndrome	Sgb Syndrome
Mental Retardation-Overgrowth Syndrome	Simpson Dysplasia Syndrome
Simpson Syndrome	Simpson-Golabi-Behmel Syndrome 1
Dysplasia Gigantism Syndrome X-Linked

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Craniosynostosis

Premature Closure Of Cranial Sutures	Craniostenosis
Craniosynostosis Syndrome	Cso
Craniosynostoses	Congenital Ossification Of Cranial Sutures
Congenital Ossification Of Sutures Of Skull	Craniostosis
Imperfect Fusion Of Skull	Congenital Imperfect Closure Skull
Imperfect Closure Skull	Premature Closure Cranium Sutures
Deficiency Of Craniofacial Axis

Omodysplasia

Omodysplasia Type 1

Omodysplasia 2

Hereditary Multiple Exostoses

Multiple Congenital Exostosis	Hereditary Multiple Exostoses 1
Hereditary Multiple Exostoses 2	Hereditary Multiple Exostoses 3
Multiple Exostosis Syndromes	Multiple Ostechondromas
Osteochondromatosis Syndrome	Exostoses Multiple Hereditary
Exostoses, Multiple Hereditary

Exostosis

Osteophyte	Exostoses
Orbital Exostosis	Exostosis Of Orbit
Bone Spur	Bony Outgrowth
Swimmer'S Exostosis	Osteophytes
External Exotoses	Cartilaginous Exostosis

Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities	Fetal Face Syndrome
Robinow Dwarfism	Mesomelic Dwarfism-Small Genitalia Syndrome
Robinow-Silverman-Smith Syndrome	Costovertebral Segmentation Defect With Mesomelia
Covesdem Syndrome	Robinow'S Syndrome
Robinow-Silverman Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05629	GPC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GPC4	RGD	RGD:1359399
Bos taurus	GPC4	VGNC	VGNC:29526
Canis familiaris	GPC4	VGNC	VGNC:41374
Felis catus	GPC4	VGNC	VGNC:67406
Mus musculus	GPC4	MGD	MGI:104902
Macaca mulatta	GPC4	VGNC	VGNC:73118

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