TSPAN5 - tetraspanin 5 Gene

Homo sapiens

Also known as NET4; NET-4; TM4SF9; TSPAN-5

Gene ID: 10098 | Gene type: protein coding

About TSPAN5

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:98,470,367-98,658,611 (from NCBI)

This gene has 10 transcripts (splice variants), 156 orthologues and 32 paralogues. Broad expression in brain (RPKM 32.0), ovary (RPKM 24.8) and 18 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

TSPAN5 Products(1)

mRNA	Protein	Name
NM_005723.4	NP_005714.2	tetraspanin-5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	23091066	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23091066	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	23091066	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	23091066	GOA
involved in protein maturation	IMP IMP: Inferred from mutant phenotype	23091066	GOA
involved in regulation of membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	28600292	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	23091066	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSPAN5 Protein Structure

Tetraspannin

0
100
200
268 a.a.

Protein Preferred Names

Protein Names

tetraspanin-5

tetraspan NET-4

TSPAN5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TSPAN5	P62079	ADAM10	Homo sapiens	O14672	Anti Bait CoIP	26686862
Intra	TSPAN5	P62079	ADAM10	Homo sapiens	O14672	Anti Tag CoIP	26686862
Intra	TSPAN5	P62079	ADAM10	Homo sapiens	O14672	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-162968	MRTF-A-IN-1	Inhibitor	/	Unkown
HY-162969	MRTF-A-IN-2	Inhibitor	/	Unkown
HY-RS15171	TSPAN5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TSPAN5	RGD	RGD:1303176
Bos taurus	TSPAN5	VGNC	VGNC:36440
Macaca mulatta	TSPAN5	VGNC	VGNC:79086
Felis catus	TSPAN5	VGNC	VGNC:66635
Canis familiaris	TSPAN5	VGNC	VGNC:47923
Mus musculus	TSPAN5	MGD	MGI:1928096

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