2. Gene
  3. TRAP1 - TNF receptor associated protein 1 Gene

TRAP1 - TNF receptor associated protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HSP75; HSP 75; HSP90L; TRAP-1

Gene ID: 10131 | Gene type: protein coding

About TRAP1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,658,037-3,717,524 (from NCBI)

This gene has 17 transcripts (splice variants), 210 orthologues and 3 paralogues. Ubiquitous expression in kidney (RPKM 31.7), heart (RPKM 25.6) and 25 other tissues.

Summary

This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

TRAP1 Products(2)

mRNA Protein Name
NM_001272049.2 NP_001258978.1 heat shock protein 75 kDa, mitochondrial isoform 2
NM_016292.3 NP_057376.2 heat shock protein 75 kDa, mitochondrial isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17579517 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
17579517 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of cellular respiration IMP
IMP: Inferred from mutant phenotype
23564345 GOA
involved in translational attenuation IMP
IMP: Inferred from mutant phenotype
24113185 GOA
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
23564345 GOA
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
23564345 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
17579517 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAP1 Protein Structure

HATPase_c_3

HATPase_c_3: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (110 - 223)

HSP90

HSP90: Hsp90 protein (291 - 701)

  • 0
  • 200
  • 400
  • 600
  • 704 a.a.
Protein Preferred Names Protein Names

heat shock protein 75 kDa, mitochondrial

TNFR-associated protein 1

Recombinant TRAP1 Proteins

Cat. No. Product Name Accession Purity
HY-P71537 TRAP1 Protein, Human (GST) Q12931 (60S-308E) ≥95%

Related Diseases

Diseases Alias
Cakut

Renal Or Urinary Tract Malformation

Congenital Anomalies Of Kidney And Urinary Tract

Congenital Anomaly Of Kidney And Urinary Tract

Congenital Anomalies Of The Kidney And Urinary Tract

Kidney And Urinary Tract, Anomalies, Congenital

Renal Hypodysplasia, Nonsyndromic, 1
Vacterl Association, X-Linked, With Or Without Hydrocephalus

VACTERLX

X-Linked Vacterl Association

Vacterl-H, X-Linked

Vacterl Association, X-Linked

Vacterl Association, X-Linked With Or Without Hydrocephalus

Vacterl Association X-Linked With Or Without Hydrocephalus

Vacterl Syndrome

Vertebral Anal Tracheoesophageal Esophageal Radial Anomalies

X-Linked Vacterl-H

Vacterl Association

Vacterl Association With Hydrocephalus
Retinitis Pigmentosa 71

RP71

Retinitis Pigmentosa, Type 71
Short-Rib Thoracic Dysplasia 10 With Or Without Polydactyly

SRTD10

Short-Rib Thoracic Dysplasia 10 Without Polydactyly

Short Rib-Polydactyly Syndrome
Vacterl Association

Vater Association

Vater Syndrome
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W111141 BCN-OH 99.15% Unkown
HY-10214 SNX-2112 99.45% Unkown
HY-10942 VER-82576 Inhibitor 98.76% Unkown
HY-117395 PU-H54 Inhibitor 99.04% Unkown
HY-115781 DN401 Inhibitor ≥99.0% Unkown
HY-147696 SMTIN-T140 99.58% Unkown
HY-155063 TRAP1-IN-1 Inhibitor / Unkown
HY-144830 6BrCaQ Inhibitor / Unkown
HY-144831 6BrCaQ-C10-TPP Inhibitor / Unkown
HY-155064 TRAP1-IN-2 Inhibitor / Unkown
HY-169369 TRAP-1 / Unkown
HY-RS14984 TRAP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TRAP1 VGNC VGNC:36283
Macaca mulatta TRAP1 VGNC VGNC:79019
Mus musculus TRAP1 MGD MGI:1915265
Felis catus TRAP1 VGNC VGNC:66507
Rattus norvegicus TRAP1 RGD RGD:1359733
Canis familiaris TRAP1 VGNC VGNC:47776
Others TRAP1 NCBI